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Phase I Clinical Study of Dose-escalation Safety, Tolerability, Pharmacokinetics, Immunogenicity and Preliminary Efficacy of Recombinant Anti-FGFR Hum...

Zhejiang Newind Biotechnology Co.

Esophageal Neoplasms; Stomach Neoplasms

Inici: 18/05/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Phase I/II Clinical Study of Mitoxantrone Hydrochloride Liposomes in Combination With Gemcitabine, Dexamethasone, and Cisplatin in Relapsed/Refractory...

Peking Union Medical College Hospital, CAMS CSPC Pharmaceutical Group Co./CSPC Ouyi Pharmaceutical Co.

Lymphoma; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell; Lymphoma, T-Cell, Peripheral

Inici: 01/05/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Single arm and single center clinical study on safety, tolerance and efficacy of GC101 injection in patients with type 1 spinal muscular atrophy

(Other Hospital/Academic/Medical Center) GeneCradle

Spinal Muscular Atrophy

Inici: 16/02/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Clinical Study on the Safety and Efficacy of Specific TIL-TCM Cells for Advanced Relapse-refractory or Metastatic Pancreatic Cancer

Shanghai Biomed-Union Biotechnology Co.

Pancreatic Neoplasms

Inici: 02/04/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Clinical Study of Safety and Tolerability of Melphalan Hydrochloride for Injection in the Treatment of Relapsed or Relapsed and Refractory Multiple My...

CASI Pharmaceuticals {EntreMed} (Other Hospital/Academic/Medical Center)

Multiple Myeloma; Neoplasms, Plasma Cell

Inici: 26/06/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I study of ZS801 injection, an rAAV gene therapy drug of Sichuan Zhishan Weixin Biotechnology Co., Ltd., in hemophilia B subjects.

Sichuan Zhishan Weixin Biotechnology Co.

Blood Coagulation Disorders; Hemophilia B; Hemostatic Disorders

Inici: 01/01/1900
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Clinical Study of TAA05 Injection in the Treatment of Adult Patients With FLT3-positive Relapsed/Refractory Acute Myeloid Leukemia

PersonGen BioTherapeutics (Suzhou) Co.

Leukemia, Myeloid, Acute

Inici: 09/06/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Open-label Study Evaluating the Safety, Tolerability and Preliminary Efficacy of XYF13 Car-T in the Patients With Recurrent Glioblastoma.

(Other Hospital/Academic/Medical Center) MingMed Biotechnology Co./Xi'an Yufan Biotechnologies Co.

Glioblastoma

Inici: 10/06/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Comparative Study of the Combined Effect of Temozolomide with Nilotinib and Temozolomide Alone on Non-surgical Newly Diagnosed Human Glioblastoma Mult...

(Other Hospital/Academic/Medical Center) Sobhan Pharmaceutical Factory

Glioblastoma

Inici: 09/03/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Clinical Trial for the Safety and Efficacy of BCMA-targeted CAR-T Cells Therapy for Refractory/Relapsed Multiple Myeloma

(Other Hospital/Academic/Medical Center) Yake Biotechnology

Multiple Myeloma; Neoplasms, Plasma Cell

Inici: 20/06/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A multi-center, open-label, balanced, randomized, two-treatment, two-period, two-sequence, two-way crossover, multiple-dose, steady-state bioequivalen...

MSN Laboratories

Carcinoma, Renal Cell; Kidney Neoplasms; Wilms Tumor

Inici: 02/05/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I Clinical Study of CD70-targeting CAR-T Therapy in the Treatment of CD70-positive Advanced/Metastatic Solid Tumors

Chongqing Precision Biotech Co.

Carcinoma, Renal Cell; Kidney Neoplasms; Neoplasm Metastasis; Neoplasms; Ovarian Neoplasms; Uterine Cervical Neoplasms; Wilms Tumor

Inici: 31/12/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I Clinical Study of CD70-targeting CAR-T Therapy in the Treatment of Advanced/Metastatic Renal Cell Carcinoma

Chongqing Precision Biotech Co.

Carcinoma; Carcinoma, Renal Cell; Kidney Neoplasms; Neoplasm Metastasis; Wilms Tumor

Inici: 31/12/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

This is a Phase I Clinical Study to Evaluate the Safety and Efficacy of CAR-T Infusion Preparation in the Treatment of CD19-positive Relapsed/Refracto...

Chongqing Precision Biotech Co.

Lymphoma; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin

Inici: 06/09/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

An Open, Single-armed, Phase I Study to Evaluate the Safety and Efficacy Using Autologous TIL in Patients With Advanced Malignant Solid Tumors

Shanghai Gencells Therapeutics Co.

Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Drug-Related Side Effects and Adverse Reactions; Head and Neck Neoplasms; Melanoma; Neoplasms; Uterine Cervical Neoplasms

Inici: 14/06/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I Clinical Study of Anti-CEA CAR-T Therapy in the Treatment of CEA-positive Advanced Malignant Solid Tumors

Chongqing Precision Biotech Co.

Colorectal Neoplasms; Esophageal Neoplasms; Neoplasm Metastasis; Pancreatic Neoplasms; Recurrence; Stomach Neoplasms

Inici: 10/09/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I, First-in-human Study of ARB202, Bispecific Antibody to CDH17 and CD3 in Advanced Gastrointestinal Malignancies

Arbele

Bile Duct Neoplasms; Cholangiocarcinoma; Cholangiocarcinoma; Colorectal Neoplasms; Gastrointestinal Neoplasms; Liver Neoplasms; Neoplasm Metastasis; Pancreatic Neoplasms; Stomach Neoplasms

Inici: 30/05/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I/II, Open-Label Study of the Safety, Pharmacokinetics, Pharmacodynamics, and Preliminary Activity of Tolinapant in Combination With Oral Deci...

Otsuka Holdings/Otsuka Pharmaceutical/Astex Pharmaceuticals

Lymphoma; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell; Lymphoma, T-Cell, Cutaneous; Lymphoma, T-Cell, Peripheral

Inici: 23/06/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Phase Ib Clinical Trial to Evaluate the Efficacy and Safety of TQB2618 Injection Combined With Pembrolizumab in Patients With Relapsed or Refractory L...

Sino Biopharmaceutical/Chia Tai Tianqing Pharmaceutical Group Co.

Hodgkin Disease; Hodgkin Lymphoma; Lymphoma; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Waldenstrom Macroglobulinemia

Inici: 01/06/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Early Clinical Study of SENL101 Autologous T Cell Injection in the Treatment of Adult Patients With Relapsed or Refractory CD7+ Hematolymphoid Maligna...

Avalon GloboCare/Hebei Senlang Biotechnology Co.

Lymphoma, Large-Cell, Anaplastic; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell; Lymphoma, T-Cell, Cutaneous; Lymphoma, T-Cell, Peripheral; Precursor Cell Lymphoblastic Leukemia-Lymphoma

Inici: 01/05/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I Clinical Study of Anti-CEA CAR-T Therapy in the Treatment of CEA-positive Advanced Malignant Solid Tumors

(Other Hospital/Academic/Medical Center) Chongqing Precision Biotech Co.

Colorectal Neoplasms; Esophageal Cancer; Esophageal Neoplasms; Neoplasm Metastasis; Neoplasms, Unknown Primary; Pancreatic Cancer; Pancreatic Neoplasms; Recurrence; Stomach Carcinoma; Stomach Neoplasms

Inici: 25/05/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I/Ib Study Evaluating Single-agent Inavolisib and Inavolisib plus Atezolizumab in PIK3CA-Mutated Cancers

Roche {F. Hoffmann-La Roche}

Head and Neck Neoplasms; Neoplasms, Unknown Primary

Inici: 16/12/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

An Open Label, Dose-escalation, 12 weeks, Phase I Study to Evaluate Safety and Pharmacodynamics of Investigational Product (VT-Tri) after Allogeneic S...

ViGenCell

Acute Myelocytic Leukemia; Leukemia, Myeloid, Acute

Inici: 03/02/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Bioequivalence test of doxorubicin hydrochloride liposome injection

Qilu Pharmaceutical Co./Qilu Pharmaceutical (Hainan) Co.

Breast Neoplasms; Ovarian Cancer; Ovarian Neoplasms

Inici: 17/05/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

To Observe the Long-term Efficacy and Safety of Dual-target Chimeric Antigen Receptor T Cells in the Treatment of Refractory Relapsed B Cell Hematolog...

(Other Hospital/Academic/Medical Center) Avalon GloboCare/Hebei Senlang Biotechnology Co.

Chronic Lymphocytic Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Unlog=C:\eq

Inici: 08/04/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I, Randomised, Open-Label, Single-Dose, Two-Treatment, Two-Way Crossover, Two-Stage Study to Evaluate the Bioequivalence of Onivyde (Irinoteca...

Ipsen

Adenocarcinoma; Pancreatic Cancer; Pancreatic Neoplasms

Inici: 30/05/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Phase I Dose Escalation Study of Mitoxantrone Hydrochloride Liposome Injection Combined with Cytarabine and Etoposide in the Treatment of Relapsed or ...

(Other Hospital/Academic/Medical Center) CSPC Pharmaceutical Group Co.

Acute Myelocytic Leukemia; Leukemia, Myeloid, Acute

Inici: 01/03/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

VRC 322/DMID 21-0016: A Phase I, Dose Escalation, Open-Label Clinical Trial to Evaluate Safety, Tolerability and Immunogenicity of a Nipah Virus (NiV)...

National Institutes of Health/National Institute of Allergy and Infectious Diseases Moderna Therapeutics

Henipavirus Infections; Virus Diseases

Inici: 01/06/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

An Exploratory Study of alphaPD1-MSLN-CAR T Cells Secreting PD-1 Nanobodies for the Treatment of MSLN-positive Advanced Solid Tumors

(Other Hospital/Academic/Medical Center) Shanghai Cell Therapy Group Co.

Bile Duct Neoplasms; Cholangiocarcinoma; Colorectal Neoplasms; Neoplasms; Neoplasms, Unknown Primary; Ovarian Cancer; Ovarian Neoplasms

Inici: 30/10/2020
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Prospective, Single-center, Exploratory Study of Low-Dose Cytarabine, Mitoxantrone Liposome Combined with Granulocyte Colony Stimulating Factor in t...

CSPC Pharmaceutical Group Co./CSPC Ouyi Pharmaceutical Co.

Acute Myelocytic Leukemia; Leukemia, Myeloid, Acute

Inici: 01/04/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I Study of CHM 1101 in Patients with Recurrent or Progressive Glioblastoma

Chimeric Therapeutics

Glioblastoma

Inici: 01/01/1900
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I Study of RG-6333 in Combination with Glofitamab in Patients with Relapsed/Refractory Non-Hodgkin Lymphoma (r/r NHL)

Roche

Lymphoma, Large-Cell, Anaplastic; Lymphoma, Non-Hodgkin

Inici: 01/01/1900
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I single-dose study to evaluate the pharmacokinetics of CORT113176 softgel capsules in healthy subjects

Corcept Therapeutics

Amyotrophic lateral sclerosis; Amyotrophic Lateral Sclerosis; Motor Neuron Disease

Inici: 17/03/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase Ib Study in Patients With Acromegaly or Functioning Gastroenteropancreatic Neuroendocrine Tumors (GEP-NETs) to Characterize the Pharmacokineti...

Debiopharm {Affinium Pharmaceuticals}

Acromegaly; Neuroendocrine Tumors

Inici: 18/05/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A randomized, single dose, open label, four-period, two-sequence, full-replicate, cross-over oral bioequivalence study between the test product, Rifap...

Cipla

Tuberculosis

Inici: 26/05/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I Clinical Trial for Evaluating the Safety, Tolerance and Efficacy of GPC3-targeting LCAR-H93T Cell in Treatment of Advanced Hepatocellular Ca...

(Other Hospital/Academic/Medical Center) Nanjing Legend Biotechnology Co.

Carcinoma; Carcinoma, Hepatocellular; Liver Cancer; Liver Neoplasms

Inici: 19/05/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Phase Ib Study Evaluating the Safety and Efficacy of Autologous CD30.CAR-T in Combination With PD-1 Checkpoint Inhibitor (Nivolumab) in Relapsed or Re...

Bristol-Myers Squibb Tessa Therapeutics {FF CanVac}

Hodgkin Disease; Hodgkin Lymphoma; Lymphoma

Inici: 30/06/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

An Open-label, Phase I Monocenter, Clinical Trial of NECVAX-NEO1 in Addition to Anti-PD-1 or Anti-PD-L1 Monoclonal Antibody Checkpoint Inhibitor Monot...

NEC Corporation/NEC OncoImmunity

Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Head and Neck Neoplasms; Kidney Neoplasms; Melanoma; Neoplasms; Neoplasms, Unknown Primary; Renal Cancer; Urethral Neoplasms; Urinary Bladder Neoplasms; Wilms Tumor

Inici: 05/05/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I Study of CCT3-AXL-0038 in Patients with Osteosarcoma and Soft Tissue Sarcoma

Exuma Biotech {F1 Oncology}

Ewing Sarcoma; Fibrosarcoma; Leiomyosarcoma; Liposarcoma; Osteosarcoma; Rhabdomyosarcoma; Sarcoma; Soft Tissue Neoplasms; Soft Tissue Sarcoma; Synovial Sarcoma

Inici: 01/01/1900
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A multicenter, randomized, open label, two treatment, three period, reference replicated, single-dose, crossover, bioequivalence study of Azacitidine ...

AbbVie/Allergan {Allergan/Actavis {Actavis {Watson Pharmaceuticals}}}

Acute Myelocytic Leukemia; Leukemia, Myeloid, Acute

Inici: 15/03/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase Ib Study of Bispecific T Cell Redirection Antibodies in Combination With Checkpoint Inhibition for the Treatment of Participants With Relapsed...

Johnson & Johnson/Janssen R&D {Johnson & Johnson/J&JPRD {Johnson & Johnson/Janssen-Cilag/Janssen Research Foundation}}

Multiple Myeloma; Neoplasms, Plasma Cell

Inici: 25/05/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I/II, Safety Confirmation and Double-blind, Placebo-controlled, Randomized Study of Relatlimab in Combination With Nivolumab and Bevacizumab i...

Bristol-Myers Squibb

Carcinoma; Carcinoma, Hepatocellular; Liver Cancer; Liver Neoplasms

Inici: 05/05/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I, Open-Label, Randomized, Two-part Parallel Study to Compare the Pharmacokinetics of Single Subcutaneous Injections of Cendakimab Administere...

Bristol-Myers Squibb

Dermatitis, Atopic; Eosinophilic Esophagitis; Unspecified

Inici: 02/05/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Multiple-dose, Randomized, Double Blind, Placebo-controlled, Dose-escalation Phase I Study to Evaluate the Safety, Tolerability, Pharmacokinetics, P...

Chengdu KeyMed Biosciences {Chengdu ConMed Biosciences}

Glomerulonephritis, IGA

Inici: 24/05/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

The Safety and Efficacy Study of Autologous Tumor-infiltrating Lymphocyte (TILs) Therapy Combined With Conventional Chemotherapy for Patients With Adv...

Avalon GloboCare/Hebei Senlang Biotechnology Co.

Glioblastoma

Inici: 15/02/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Randomized, Single-dose, Open-label, Two-part, Two-period, Cross-over Study to Compare the Pharmacokinetics, Safety and Tolerability of the Pediatric ...

Novartis

Amyotrophic lateral sclerosis; Amyotrophic Lateral Sclerosis; Huntington Disease; Motor Neuron Disease; Unspecified

Inici: 13/04/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Phase 1 open-label study of S-770108 in patients with idiopathic pulmonary fibrosis-safety, tolerability, and pharmacokinetics of repeated doses

Shionogi

Idiopathic Pulmonary Fibrosis; Pulmonary Fibrosis

Inici: 28/02/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase 1b Study Evaluating the Safety, Tolerability, and Pharmacokinetics of Bemarituzumab in Combination With Other Anti-cancer Therapies in Subject...

Amgen

Esophageal Cancer; Esophageal Neoplasms; Stomach Carcinoma; Stomach Neoplasms

Inici: 17/05/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase 1b/2a Open-label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DISC-0974 in Participants With Myelofib...

Disc Medicine

Anemia; Myeloproliferative Disorders; Palliative Care; Polycythemia; Polycythemia Vera; Primary Myelofibrosis; Thrombocythemia, Essential; Thrombocytosis

Inici: 06/06/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

An Open-label, Single-arm, Multi-center, Phase I/II Study to Evaluate the Safety, Tolerability, and Efficacy of AT101 (Anti-CD19 Chimeric Antigen Rece...

AbClon

Lymphoma; Lymphoma, B-Cell; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Waldenstrom Macroglobulinemia

Inici: 15/03/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I, Open-label Clinical Study to Evaluate the Safety, Tolerability, and Efficacy of LCAR-AIO, a Triple-targeted Cell Preparation Targeting CD19...

Institute of Hematology & Blood Diseases Hospital Nanjing Legend Biotechnology Co.

Lymphoma; Lymphoma, B-Cell; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Waldenstrom Macroglobulinemia

Inici: 14/03/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Pilot Study of Siltuximab in Large Granular Lymphocytic Leukemia (LGLL)

H. Lee Moffitt Cancer Center and Research Institute EUSA Pharma {Jazz Pharmaceuticals/EUSA Pharma {Cytogen}}

Chronic Lymphocytic Leukemia; Leukemia; Leukemia, Large Granular Lymphocytic; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Lymphoid

Inici: 29/03/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I Clinical Trial of an Infusion of Autologous T Cells Genetically Engineered With a Chimeric Receptor to Target the Follicle-Stimulating Hormo...

H. Lee Moffitt Cancer Center and Research Institute Anixa Biosciences

Carcinoma, Ovarian Epithelial; Fallopian Tube Neoplasms; Ovarian Cancer; Ovarian Neoplasms; Peritoneal Neoplasms

Inici: 30/03/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase 1 study of buntanetap in Frontotemporal Dementia.

Annovis Bio {QR Pharma}

Dementia; Frontotemporal Dementia

Inici: 01/01/1900
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I Feasibility And Safety Study of Fluorescein-Specific (FITC-Ew) CAR T Cells In Combination With Parenterally Administered Folate-Fluorescein ...

Seattle Children''s Hospital Umoja BioPharma

Ewing Sarcoma; Osteosarcoma; Sarcoma

Inici: 20/05/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

First-in-Human Study of the BCL-2 Inhibitor ABBV-453 in Biomarker-Selected Subjects With Relapsed or Refractory Multiple Myeloma

AbbVie

Multiple Myeloma; Neoplasms, Plasma Cell

Inici: 17/05/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I Clinical Study of Autologous HBV-specific TCR-T Cell Therapy (SCG101) in Patients With HBV-related HCC

(Other Hospital/Academic/Medical Center) SCG Science (Dalian) Co.

Carcinoma, Hepatocellular; Liver Cancer; Liver Neoplasms

Inici: 14/04/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Single-center, randomized, open-label, two-agent, single-dose, two-cycle, double-crossover, bioequivalence trail of test preparation Macitentan Tabl...

Nanjing Zeheng Pharmaceutical Technology Development Co.

Hypertension; Hypertension, Pulmonary

Inici: 15/04/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I, Randomized, Open-label, Parallel-group Study to Compare the Pharmacokinetic Properties of CSL312 Administered by Subcutaneous Prefilled Syr...

CSL Limited/CSL Behring/Vitaeris

Angioedemas, Hereditary; Pulmonary Fibrosis; Thrombosis; Unspecified

Inici: 04/04/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Clinical Study of a Personalized Neoantigen Vaccine in Esophagus Cancer Patients Who Have Completed Adjuvant Therapy Following Neoadjuvant Therapy and...

(Other Hospital/Academic/Medical Center) Hangzhou Neoantigen Therapeutics Co.

Esophageal Cancer; Esophageal Neoplasms

Inici: 02/12/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Two-part, Open-label, Clinical Study to Assess the Safety, Tolerability and Activity of Intravenous Doses of ICT01 in Combination With Low-dose Subc...

ImCheck Therapeutics

Colorectal Neoplasms; Neoplasms; Neoplasms, Unknown Primary; Ovarian Cancer; Ovarian Neoplasms; Pancreatic Cancer; Pancreatic Neoplasms; Prostatic Neoplasms

Inici: 19/04/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Early Phase I Clinical Trial To Evaluate the Safety and Efficacy of Human Derived Anti-BCMA CAR-T Injection for Subjects With Relapsed/Refractory Mu...

(Other Hospital/Academic/Medical Center) Hrain Biotechnology Co.

Multiple Myeloma; Neoplasms, Plasma Cell

Inici: 09/02/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase Ib/IIa, Open-Label, Dose-Escalation Study of the Safety and Efficacy of an Anti-CD38 Antibody Drug Conjugate (STI-6129) in Patients With Relap...

Sorrento Therapeutics

Multiple Myeloma; Neoplasms, Plasma Cell

Inici: 01/03/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Phase I Clinical Study of TQB2618 Injection in Combination With Demethylation Drugs in Patients With Recurrent/Refractory Acute Myeloid Leukemia, Myel...

Sino Biopharmaceutical/Chia Tai Tianqing Pharmaceutical Group Co.

Acute Myelocytic Leukemia; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes

Inici: 29/04/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I, Randomized, Double-Blind, Placebo-Controlled, Single- and Multiple-Dose Dose Escalation to Evaluate the Safety, Tolerability, Pharmacokinet...

(Other Hospital/Academic/Medical Center) AceLink Therapeutics/AceLink Therapeutics (Suzhou) Co.

Fabry Disease

Inici: 09/06/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I/IIa Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Antitumor Activity of JAB-21822 in Combination With JAB-3312 i...

Beijing Jacobio Pharmaceuticals Co.

Carcinoma, Ductal; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Colorectal Neoplasms; Neoplasms, Unknown Primary; Pancreatic Cancer; Pancreatic Neoplasms

Inici: 14/04/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Phase I clinical study of the safety, tolerability, and pharmacokinetics of injectable TB001 after single and multiple subcutaneous injections in heal...

(Other Hospital/Academic/Medical Center) Shenzhen Turier Biotech Co.

Tuberculosis

Inici: 01/10/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Clinical Trial to Evaluate the Safety and Efficacy of IM96 CAR-T Cells Therapy in Patients With Advanced Digestive System Neoplasms

Beijing Immunochina Medical Science & Technology Co.

Colorectal Neoplasms; Digestive System Neoplasms; Gastrointestinal Neoplasms; Neoplasms; Neoplasms, Unknown Primary; Pancreatic Cancer; Pancreatic Neoplasms; Stomach Carcinoma; Stomach Neoplasms

Inici: 10/03/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

CC-486 and Venetoclax for Acute Myeloid Leukemia

Bristol-Myers Squibb University of Colorado

Acute Myelocytic Leukemia; Leukemia, Myeloid, Acute

Inici: 15/03/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

An Open-label Phase 1, Pharmacokinetic and Tolerability Study of Tolebrutinib Given as a Single Dose in Adult Participants With Mild Hepatic Impairmen...

Sanofi

Multiple Sclerosis; Multiple Sclerosis, Chronic Progressive; Multiple Sclerosis, Chronic Progressive; Myasthenia Gravis; Relapsing-Remitting Multiple Sclerosis; Unspecified

Inici: 18/03/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Translational Phase I/II Dose-Escalation and Expansion Study to Determine Safety, Tolerability, and Recommended Phase II Dose of RSO-021 in Patients...

RS Oncology

Mesothelioma; Mesothelioma, Malignant; Neoplasms, Mesothelial; Neoplasms, Unknown Primary; Pleural Effusion; Pleural Effusion, Malignant

Inici: 04/04/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

An Open-label, Multi-center Phase 1 Pharmacokinetic and Tolerability Study of Tolebrutinib Given as a Single Oral Dose in Participants With Renal Impa...

Sanofi

Multiple Sclerosis; Myasthenia Gravis; Renal Insufficiency

Inici: 23/03/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase Ib/II, Single Center, Open-Label, Safety and Efficacy Study to Improve Anemia in Subjects on Enasidenib With Lower Risk Myelodysplastic Syndro...

Bristol-Myers Squibb/Celgene

Anemia; Leukemia; Leukemia, Myeloid; Leukemia, Myelomonocytic, Chronic; Leukemia, Myelomonocytic, Juvenile; Myelodysplastic Syndromes; Palliative Care

Inici: 12/01/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Randomized, Double-Blind, Placebo-Controlled, Multi-center, Multiple Ascending Dose Study to Assess the Safety, Tolerability, and Pharmacokinetics o...

Eisai

Lupus Erythematosus, Cutaneous; Lupus Erythematosus, Systemic; Systemic Lupus Erythematosus

Inici: 18/03/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Clinical Study on the Safety and Effectiveness of CART Cells in the Treatment of Advanced Gynecological Tumors

(Other Hospital/Academic/Medical Center) Innovative Cellular Therapeutics Co.

Carcinoma, Endometrioid; Endometrial Neoplasms; Fallopian Tube Neoplasms; Ovarian Cancer; Ovarian Neoplasms; Uterine Cervical Neoplasms

Inici: 09/03/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I Study of BMF-219 for the Treatment of Multiple Myeloma (MM) and Diffuse Large B-cell Lymphoma (DLBCL)

Biomea Fusion

Lymphoma, Large B-Cell, Diffuse; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Non-Hodgkin; Multiple Myeloma

Inici: 01/06/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Clinical Trial to Evaluate the Safety and Efficacy of IM92 CAR-T Cells Therapy in Patients With Advanced Gastric or Pancreatic Adenocarcinoma

Beijing Immunochina Medical Science & Technology Co.

Adenocarcinoma; Esophageal Cancer; Esophageal Neoplasms; Pancreatic Cancer; Pancreatic Neoplasms; Stomach Carcinoma; Stomach Neoplasms

Inici: 15/02/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Single-Arm, Dose-Escalating Phase I Clinical Study To Evaluate The Safety, Biodistribution And Preliminary Efficacy Of Recombinant Human PD-1 Antibo...

(Other Hospital/Academic/Medical Center) Zhejiang Yangshengtang Biotech Co.

Glioblastoma

Inici: 07/12/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I/Ib Study of ASP2138 in Participants With Metastatic or Locally Advanced Unresectable Gastric or Gastroesophageal Junction (GEJ) Adenocarcino...

Xencor Astellas Pharma/Astellas Pharma Global Development

Esophageal Cancer; Esophageal Neoplasms; Pancreatic Cancer; Pancreatic Neoplasms; Stomach Carcinoma; Stomach Neoplasms

Inici: 07/06/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

An Open label, Single-arm Clinical Study Evaluating the Safety and Efficacy of IBI346 Infusion in Relapsed/Refractory Multiple Myeloma

(Other Hospital/Academic/Medical Center) Innovent Biologics (Suzhou) Co.

Multiple Myeloma; Neoplasms, Plasma Cell

Inici: 28/02/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase 1, Open-Label, Multiple-Dose, Parallel Study to Determine the Effect of Hepatic Impairment on the Pharmacokinetics, Safety, and Tolerability o...

AstraZeneca/Alexion Pharmaceuticals

Anemia; Myasthenia Gravis; Paroxysmal Hemoglobinuria; Unspecified

Inici: 07/04/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Randomized, Open Label, Multi-centre, Two-treatment, Two-period, Two-sequence, Two-stage, Multiple Dose, Steady-state, Crossover, Bioequivalence Stu...

Novartis/Sandoz/Lek d.d.

Breast Neoplasms; Carcinoma, Ovarian Epithelial; Fallopian Tube Neoplasms; Ovarian Cancer; Ovarian Neoplasms; Peritoneal Neoplasms

Inici: 07/04/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

AMG 701 Expanded Access Program

Amgen

Multiple Myeloma; Unspecified

Inici: 25/02/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Clinical Study on the Safety and Effectiveness of CLL1 CAR-T Cells in the Treatment of CLL1-positive Hematological Malignancies

(Other Hospital/Academic/Medical Center) Yake Biotechnology

Acute Myelocytic Leukemia; Hematologic Neoplasms; Leukemia, Myeloid, Acute

Inici: 28/02/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Expanded Access Program Of TAS-116 (Pimitespib) In Patients With Advanced Gastrointestinal Stromal Tumor

Otsuka Holdings/Taiho Pharmaceutical

Gastrointestinal Stromal Tumors

Inici: 01/02/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

NKG2D CAR-NK Cell Therapy in Patients With Relapsed or Refractory Acute Myeloid Leukemia

Hangzhou Cheetah Cell Therapeutics Co.

Acute Myelocytic Leukemia; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute

Inici: 13/10/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

An Open Label Trial of BI 765063 in Combination With BI 754091 (Ezabenlimab) Alone or With BI 836880, Chemotherapy, or Cetuximab, in Patients With Rec...

Boehringer Ingelheim

Carcinoma; Carcinoma, Hepatocellular; Carcinoma, Squamous Cell; Head and Neck Neoplasms; Liver Cancer; Liver Neoplasms; Squamous Cell Carcinoma of Head and Neck

Inici: 25/02/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Early-Phase Open-label Study of Tolinapant and Radiation in Cisplatin-Ineligible Patients With Previously Untreated, Locally Advanced Head and Neck Ca...

(Other Hospital/Academic/Medical Center) Otsuka Holdings/Otsuka Pharmaceutical/Astex Pharmaceuticals

Carcinoma; Carcinoma, Squamous Cell; Head and Neck Neoplasms; Squamous Cell Carcinoma of Head and Neck

Inici: 17/02/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Phase I clinical study of the safety, tolerability, pharmacokinetics and pharmacodynamics of HSK31858 tablets in healthy subjects and the effect of fo...

Haisco Pharmaceutical Group Co.

Bronchiectasis

Inici: 19/02/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase Ib, Open-Label, Multicenter, Dose-Escalation Study to Evaluate the Safety and Pharmacokinetics of XMAB24306 in Combination With Daratumumab in...

Roche/Genentech

Multiple Myeloma; Neoplasms, Plasma Cell

Inici: 28/04/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I, Multicenter, Open-label Study of BMS-986403 in Subjects With Relapsed and/or Refractory Chronic Lymphocytic Leukemia (CLL) or Small Lymphoc...

Bristol-Myers Squibb

Chronic Lymphocytic Leukemia; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Lymphoid; Lymphoma; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Non-Hodgkin

Inici: 27/05/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Multicenter, Open Label, Randomized, Balanced, Two-treatment, Two-period, Two-sequence, Single Dose, Cross-over Bioequivalence Study of Doxorubicin ...

Sun Pharmaceutical Industries

Fallopian Tube Neoplasms; Ovarian Cancer; Ovarian Neoplasms; Peritoneal Neoplasms

Inici: 20/01/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Clinical Study on the Safety and Effectiveness of Autologous Hematopoietic Stem Cell Transplantation Combined With CAR-T Cells in the Treatment of Ref...

(Other Hospital/Academic/Medical Center) Yake Biotechnology

Lymphoma; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Non-Hodgkin; Precursor Cell Lymphoblastic Leukemia-Lymphoma

Inici: 15/02/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Clinical Study on the Safety and Effectiveness of CD38 CAR-T Cells in the Treatment of CD38-positive Hematological Malignancies

(Other Hospital/Academic/Medical Center) Yake Biotechnology

Acute Myelocytic Leukemia; Hematologic Neoplasms; Leukemia, Myeloid, Acute

Inici: 28/02/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Clinical Study on the Safety and Effectiveness of Targeting CD7 Chimeric Antigen Receptor T Cells in the Treatment of Autoimmune Diseases

(Other Hospital/Academic/Medical Center) Yake Biotechnology

Arthritis, Rheumatoid; Autoimmune Diseases; Colitis; Colitis, Ulcerative; Crohn Disease; Dermatomyositis; Dermatomyositis; Inflammatory Bowel Diseases; Polymyositis; Rheumatoid Arthritis; Ulcer

Inici: 15/02/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Randomized, Double-blind, Placebo-controlled, Single-center, Single and Multiple Oral Dose Study to Evaluate the Safety, Tolerability, and Pharmacok...

Aculys Pharma

No disponible

Inici: 12/01/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase 1b, Single Ascending Dose, Randomized, Double-blind Study to Evaluate the Safety, Tolerability, and Activity of SAR439459 in Adults With Osteo...

Sanofi

Osteogenesis Imperfecta; Osteoporosis

Inici: 22/03/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I Study of SGN-ALPV in Advanced Solid Tumors

Seagen

Carcinoma, Endometrioid; Carcinoma, Non-Small-Cell Lung; Endometrial Neoplasms; Neoplasms; Ovarian Cancer; Ovarian Neoplasms; Stomach Carcinoma; Stomach Neoplasms; Testicular Cancer; Testicular Neoplasms; Uterine Cervical Neoplasms

Inici: 21/03/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I Trial to Evaluate the Safety and Tolerability of Fb-PMT in Patients With Recurrent Glioblastoma

NanoPharmaceuticals LLC

Glioblastoma; Glioma

Inici: 10/05/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

An Open-Label Phase Ia/Ib Dose Escalation and Expansion Cohort Study of SL-172154 (SIRPa-Fc-CD40L) in Combination With Azacitidine or With Azacitidine...

Shattuck Labs

Acute Myelocytic Leukemia; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Preleukemia

Inici: 15/03/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

An Ascending Single Oral Dose, Double-Blind, Randomized, Placebo-Controlled Study Assessing The Safety, Tolerability, and Pharmacokinetics of DSP-0187...

Sumitomo Dainippon Pharma {Dainippon Sumitomo}

No disponible

Inici: 02/12/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Expanded Access of LOXO-260 in Participants With RET Mutant or RET Fusion Tumors Refractory to Prior RET Selective TKI Treatment

Eli Lilly/Loxo Oncology

Carcinoma, Non-Small-Cell Lung; Thyroid Neoplasms

Inici: 01/01/1900
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

An Exploratory Study of Fully Human Anti-GPRC5D Chimeric Antigen Receptor T Cells (CAR-GPRC5D) in Patients With Relapsed/Refractory Multiple Myeloma o...

(Other Hospital/Academic/Medical Center) Nanjing Iaso Biotherapeutics Co./Shanghai Iaso Biotechnology Co.

Leukemia; Leukemia, Plasma Cell; Multiple Myeloma; Neoplasms, Plasma Cell

Inici: 17/03/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase Ib/II Pressure Enabled Regional Immuno-Oncology Study of Hepatic Arterial Infusion of SD-101 With Systemic Checkpoint Blockade for Hepatocellu...

TriSalus Life Sciences

Bile Duct Neoplasms; Carcinoma; Carcinoma, Hepatocellular; Cholangiocarcinoma; Cholangiocarcinoma; Liver Cancer; Liver Neoplasms

Inici: 02/03/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

An Open-Label, Phase I Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of RO7443904 in Combination With Glofita...

Roche {F. Hoffmann-La Roche}

Lymphoma; Lymphoma, B-Cell; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Non-Hodgkin

Inici: 18/02/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I/II Open-label, Multi-center Study to Assess Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of AZD7789, an Anti-PD-1 and Ant...

AstraZeneca

Hodgkin Disease; Hodgkin Lymphoma; Lymphoma

Inici: 18/03/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

An Open Label, Phase Ib/II Trial of LVGN6051 Combined With Anlotinib in the Treatment of Locally Advanced, Metastatic or Recurrent Refractory Soft Tis...

Lyvgen Biopharma Holdings

Fibrosarcoma; Leiomyosarcoma; Liposarcoma; Rhabdomyosarcoma; Sarcoma; Soft Tissue Neoplasms; Soft Tissue Sarcoma; Synovial Sarcoma

Inici: 25/05/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Clinical Study of Conjugated Antibody Redirecting Natural Killer (CAR-NK) Cells Targeting CD33 and CLL1 in Patients With Acute Myeloid Leukemia

(Other Hospital/Academic/Medical Center) Imbioray (Hangzhou) Biomedicine Co.

Acute Myelocytic Leukemia; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute

Inici: 30/11/2020
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

CD7 CAR-T Cell Treatment of Relapsed/Refractory CD7+ T - Acute Lymphoblastic Leukemia/ Lymphoma

iCell Gene Therapeutics Crane Precision Immunotherapy Co.

Hematologic Neoplasms; Leukemia; Leukemia, Lymphoid; Lymphoma; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell, Peripheral; Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lympho??

Inici: 01/11/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

AUGMENT-102: A Phase I, Open-label, Dose-escalation Study to Evaluate Safety, Tolerability and Preliminary Anti-Leukemic Activity of SNDX-5613 in Comb...

Syndax

Acute Myelocytic Leukemia; Leukemia; Leukemia, Myeloid, Acute; Precursor Cell Lymphoblastic Leukemia-Lymphoma

Inici: 09/03/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I/II, Multi-Center, Open-Label Study to Evaluate the Safety, Tolerability, and Preliminary Anti-tumor Activity of TNG908 in Patients With MTAP...

Tango Therapeutics

Bile Duct Neoplasms; Carcinoma, Non-Small-Cell Lung; Cholangiocarcinoma; Glioblastoma; Mesothelioma; Neoplasms; Neoplasms, Mesothelial; Neoplasms, Unknown Primary; Pancreatic Cancer; Pancreatic Neoplasms

Inici: 23/03/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Relative Bioavailability of 40 mg/0.4 mL of BI 695501 Compared to 40 mg/0.8 mL of BI 695501 Formulation Following Single Subcutaneous Administration i...

Boehringer Ingelheim

Arthritis; Arthritis, Juvenile; Arthritis, Rheumatoid; Colitis, Ulcerative; Crohn Disease; Hidradenitis Suppurativa; Inflammatory Bowel Diseases; Psoriasis; Psoriatic Arthritis; Rheumatoid Arthritis; Spondylitis, Ankylosing; Unspecified

Inici: 18/02/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Two-part, Randomized, Investigator- and Participant- Blinded, Placebo-controlled, Multiple Ascending Dose Study to Assess the Safety, Tolerability, ...

Novartis

Lupus Erythematosus, Cutaneous; Lupus Erythematosus, Systemic; Systemic Lupus Erythematosus

Inici: 15/03/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Phase I Clinical Study of a Fully Human BCMA-targeting CAR (CT103A) Combined With Selinexor in the Treatment of Patients With Relapsed/Refractory Extr...

(Other Hospital/Academic/Medical Center) Nanjing Iaso Biotherapeutics Co.

Multiple Myeloma; Neoplasms, Plasma Cell

Inici: 01/01/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Single Arm, Single Dose Study to Characterize the Biodistribution of 124I-Labeled AT-03 in Select Organs in Patients With Systemic Amyloidosis

Attralus

Amyloidosis; Immunoglobulin Light-chain Amyloidosis

Inici: 30/11/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Phase Ib Clinical Study to Evaluate the Safety and Efficacy of TQB2858 Injection to the Subjects With Recurrent/Metastatic Nasopharyngeal Cancer

Sino Biopharmaceutical/Chia Tai Tianqing Pharmaceutical Group Co.

Head and Neck Neoplasms; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms

Inici: 01/01/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase Ia Study to Evaluate the Safety, Tolerance, Pharmacokinetics and Preliminary Efficacy of IBI345 in Patients With CLDN18.2-positive Solid Tumor...

Innovent Biologics (Suzhou) Co.

Esophageal Cancer; Esophageal Neoplasms; Stomach Carcinoma; Stomach Neoplasms; Unspecified

Inici: 13/12/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I Study of CAR-T Cells in Patients with Multiple Myeloma and Acute Lymphoblastic Leukaemia (ALL)

Kolmar Korea/HK inno.N

Multiple Myeloma; Precursor Cell Lymphoblastic Leukemia-Lymphoma

Inici: 01/01/1900
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Phase 1 Randomized, Dose-finding Study to Evaluate the Safety, Tolerability and Immunogenicity of a Novel Malaria Vaccine, MSP3-CRM-Vac4All/ Alhydroge...

Vac4All

Malaria; Malaria, Falciparum

Inici: 01/12/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Human bioavailability of fixed-dose anti-tuberculosis compound preparations

Henan Kangli Medicine Technology Co. Zhengzhou Shenghua Pharmaceutical and Food Technology Development Co.

Tuberculosis

Inici: 31/10/2012
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I/II Study of Bomedemstat Combined With Maintenance Immunotherapy for Patients With Newly Diagnosed Extensive Stage Small Cell Lung Cancer (ES...

National Institutes of Health/National Cancer Institute University of Washington Imago BioSciences

Carcinoma; Carcinoma, Small Cell; Neuroendocrine Tumors; Small Cell Lung Carcinoma

Inici: 11/04/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

An Open-Label, Multi-Center, Phase Ib/II Study to Evaluate the Safety, Tolerability and Pharmacokinetic Characteristics of Tetra-specific Antibody GNC...

Biokin Pharmaceutical/Sichuan Baili Pharmaceutical Co. Biokin Pharmaceutical/SystImmune

Lymphoma; Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Non-Hodgkin

Inici: 14/12/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Bioequivalence study of ethambutol hydrochloride tablets in healthy subjects

Guangdong Zhongsheng Pharmaceutical Co./Guangdong Huanan Pharmaceutical Group Co.

Tuberculosis

Inici: 01/01/1900
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

An Open-label, Multicenter, Phase I Study Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Clinical Activity o...

Roche {F. Hoffmann-La Roche}

Glioblastoma

Inici: 05/04/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

To Evaluate the Multi-center, Open, Single-arm Phase I/II Clinical Study of Recombinant Humanized Anti-CD47/PD-1 Bifunctional Antibody HX009 Injection...

Hangzhou Hansi Biomedical Co. Waterstone Hanxbio

Hodgkin Disease; Hodgkin Lymphoma; Lymphoma; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell, Peripheral

Inici: 31/12/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Clinical Study of PTX-061 in Patients with Acute Myeloid Leukaemia

Pleco Therapeutics

Acute Myelocytic Leukemia; Leukemia, Myeloid, Acute

Inici: 01/01/1900
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A multicenter, open-label, phase Ib/II study of the efficacy and safety of F520 combined with lenvatinib in patients with advanced solid tumor

Lunan Pharmaceutical Group Corporation/Shandong New Time Pharmaceutical Co.

Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Endometrial Neoplasms; Kidney Neoplasms; Neoplasms, Unknown Primary; Urethral Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms; Wilms Tumor

Inici: 23/05/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase 0/Ib, Single Center, Clinical Trial With an Expansion Phase of AZD1390 Plus Fractionated Radiotherapy in Recurrent WHO Grade IV Glioma Patient...

AstraZeneca (Other Hospital/Academic/Medical Center)

Glioblastoma; Glioma

Inici: 09/03/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A single-dose, randomized, open-label, crossover bioequivalence study of ethambutol hydrochloride tablets and Ebutol in healthy subjects under fasting...

Shenyang Hongqi Pharmaceutical Co.

Tuberculosis

Inici: 23/10/2018
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Randomized, Open-Label, Multicenter, Two Treatment, Two Period, Two Sequence, Single Dose, Crossover Bioequivalence Study Of Doxorubicin Hydrochlori...

Alembic Pharmaceuticals

Ovarian Cancer; Ovarian Neoplasms

Inici: 01/03/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A single-dose, randomized, open-label, crossover bioequivalence study of ethambutol hydrochloride tablets and Ebutol in healthy subjects after meals

Shenyang Hongqi Pharmaceutical Co.

Tuberculosis

Inici: 28/10/2018
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Randomized Phase I/ II Multicenter Study Evaluating Combination of Luspatercept in LR-MDS Without RS Having Failed or Being Ineligible to ESA

(Other Cooperative Group) Bristol-Myers Squibb/Celgene

Myelodysplastic Syndromes

Inici: 18/05/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A randomized open-label single-dose double-crossover bioequivalence study of ethambutol hydrochloride capsules in healthy subjects on an empty stomach...

Shenyang Hongqi Pharmaceutical Co.

Tuberculosis

Inici: 19/11/2018
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase 1, First Time in Human Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of NST 6179 in Healthy Subjects

NorthSea Therapeutics

Liver Diseases; Short Bowel Syndrome

Inici: 07/12/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase 1 Randomized, Single Center, Double-Blind, Placebo-Controlled, Dose-Response Study to Evaluate the Safety and Immunogenicity of rVSV-Nipah Vir...

Coalition for Epidemic Preparedness Innovations (CEPI) Public Health Vaccines

Henipavirus Infections; Virus Diseases

Inici: 10/01/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I Study to Assess the Safety, Tolerability, Pharmacokinetics of DZD8586 in Healthy Adult Participants

Dizal (Jiangsu) Pharmaceutical Co. (AstraZeneca and SDIC Fund Management Company joint venture)

Lymphoma, Large-Cell, Anaplastic; Lymphoma, Non-Hodgkin

Inici: 09/12/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I, Open-Label, Single-Sequence Study to Evaluate Potential Disease-Mediated Drug-Drug Interaction With Selected Cytochrome P450 Substrates in ...

Bristol-Myers Squibb/Celgene

Eosinophilic Esophagitis; Esophagitis

Inici: 07/06/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Single arm and single center clinical study on safety, tolerance and efficacy of GC101 injection in patients with type 2 and 3 spinal muscular atrophy...

(Other Hospital/Academic/Medical Center) GeneCradle

Muscular Atrophy, Spinal; Spinal Muscular Atrophy

Inici: 15/12/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

An Open, Multi-Center Phase Ib Clinical Study Of A166 For Injection In The Treatment Of HER2-Positive Locally Advanced Or Metastatic Gastric Cancer Or...

Sichuan Kelun Pharmaceutical Co./Sichuan Kelun Botai Biopharmaceutical Co.

Esophageal Cancer; Esophageal Neoplasms; Stomach Carcinoma; Stomach Neoplasms

Inici: 15/01/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Phase I Clinical study on the Safety and efficacy of CART cells in the treatment of Advanced Pancreatic Cancer

(Other Hospital/Academic/Medical Center) Innovative Cellular Therapeutics Co.

Pancreatic Cancer; Pancreatic Neoplasms

Inici: 22/01/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase 1b, Multicenter, Open-Label Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Efficacy of Mezagitamab (TAK-079) in Patients With P...

Takeda

Glomerulonephritis, IGA; Kidney Diseases

Inici: 17/07/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

The Safety, Tolerability, and Pharmacokinetic Characteristics of DXC007 (Recombinant Humanized Anti-CD33 Monoclonal Antibody-Tub255 Conjugate) for Inj...

Hangzhou DAC Biotech Co.

Acute Myelocytic Leukemia; Chronic Lymphocytic Leukemia; Chronic Myeloid Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Precursor Cell Lymphoblastic Leukemia-Lymphoma

Inici: 01/01/1900
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Double Blind, Randomized, Placebo-Controlled, Phase 1 Dose Escalation Trial to Evaluate the Safety and Immunogenicity of an Inactivated Yellow Fever...

National Institutes of Health/National Institute of Allergy and Infectious Diseases Najit Technologies

Fever; Yellow Fever

Inici: 13/01/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Expanded Access Program for Pirtobrutinib for Previously Treated B-Cell Cancers

Eli Lilly/Loxo Oncology

Chronic Lymphocytic Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Lymphoid; Lymphoma; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Waldenstrom Macroglobulinemia

Inici: 01/01/1900
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I Study of Magrolimab in Children and Adults With Recurrent or Progressive Malignant Brain Tumors

Gilead Sciences University of California, San Francisco

Brain Neoplasms; Glioblastoma; Neoplasms

Inici: 22/04/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Randomized, Open, Multicenter Phase Ib Clinical Study of F0002-ADC in Patients with Relapsed/Refractory CD30-Positive Peripheral T-cell Lymphoma

Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Shanghai Pharmaceuticals Holding Co./Shanghai Jiaolian Drug Development Co.

Lymphoma, Large-Cell, Anaplastic; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell, Peripheral

Inici: 29/11/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase 1 Combined Single and Multiple Ascending Oral Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ASP873...

Astellas Pharma/Astellas Pharma Global Development

Anemia, Sickle Cell; Sickle Cell Anemia; Sickle Cell Trait; Unspecified

Inici: 07/03/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I First-in-Human, Drug-dose Escalation Study of RM-1995 Photoimmunotherapy, as Monotherapy or Combined With Pembrolizumab, in Patients With Ad...

Rakuten Medical

Carcinoma; Carcinoma, Squamous Cell; Head and Neck Neoplasms; Squamous Cell Carcinoma of Head and Neck

Inici: 24/03/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Phase 1 clinical trial to evaluate the pharmacokinetic (PK) profile, efficacy and safety of Amikacin Cyclops

Groningen University Hospital PureIMS

Tuberculosis

Inici: 01/01/1900
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I, First in Human, Dose-Escalation Study of TORL-2-307-MAB in Participants With Advanced Cancer

(Other Academic Cancer Center) TORL Biotherapeutics

Esophageal Cancer; Esophageal Neoplasms; Neoplasms, Unknown Primary; Pancreatic Cancer; Pancreatic Neoplasms; Stomach Carcinoma; Stomach Neoplasms

Inici: 20/01/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A phase I Clinical Study of SIM1811-03 injection intended to treat advanced solid tumors and skin T-cell lymphoma

Simcere Pharmaceutical Group {Jiangsu Simcere Pharmaceutical Co.}

Lymphoma, Large-Cell, Anaplastic; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell, Cutaneous; Lymphoma, T-Cell, Peripheral; Neoplasms, Unknown Primary

Inici: 16/03/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A randomized, double-blind, placebo-controlled, multiple-dose escalation clinical study to evaluate the safety, tolerability and pharmacokinetic chara...

Chongqing Dikang Changjiang Pharmaceutical Co.

Hypertension; Hypertension, Pulmonary

Inici: 23/11/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase Ib/II, Open-Label, Multicenter, Randomized Umbrella Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients Wi...

Roche {F. Hoffmann-La Roche} Roche/Genentech

Carcinoma; Esophageal Cancer; Esophageal Neoplasms; Stomach Carcinoma; Stomach Neoplasms

Inici: 23/02/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase Ib/II Open Label Dose Confirmation, Proof of Concept Study of Siremadlin in Combination With Venetoclax Plus Azacitidine in Unfit Adult AML Pa...

Novartis

Acute Myelocytic Leukemia; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute

Inici: 10/05/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I Study of Safety, Tolerability and Pharmacokinetics of T-1301 Capsules in Subjects With Advanced Solid Tumors

Taivex Therapeutics

Hodgkin Disease; Hodgkin Lymphoma; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Non-Hodgkin; Neoplasms; Neoplasms, Unknown Primary

Inici: 19/12/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase 1/2a Study of the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Subcutaneously Administered CDK-003 in Healthy Adult Particip...

Codiak BioSciences

Lymphoma; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell; Lymphoma, T-Cell, Cutaneous

Inici: 09/08/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I, First in Human, Dose-Escalation Study of TORL-2-307-ADC in Participants With Advanced Cancer

Organisation for Oncology and Translational Research TORL Biotherapeutics

Esophageal Cancer; Esophageal Neoplasms; Neoplasms, Unknown Primary; Pancreatic Cancer; Pancreatic Neoplasms; Stomach Carcinoma; Stomach Neoplasms

Inici: 02/02/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase Ib/II, Open-Label Study To Evaluate The Safety, Pharmacokinetics, Pharmacodynamics, And Efficacy Of Elranatamab (PF-06863135) In Chinese Parti...

Pfizer

Multiple Myeloma; Neoplasms, Plasma Cell

Inici: 21/12/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Single-arm, Open phase II Clinical study of Albumin Paclitaxel combined with Anlotinib in the treatment of Platinum-resistant Relapsed Ovarian Cance...

(Other Hospital/Academic/Medical Center) Sino Biopharmaceutical/Chia Tai Tianqing Pharmaceutical Group Co. Jiangsu Hengrui Pharmaceuticals Co.

Fallopian Tube Neoplasms; Ovarian Cancer; Ovarian Neoplasms; Peritoneal Neoplasms

Inici: 10/10/2020
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Phase I study of ITK inhibitors in the treatment of Relapsed and Refractory T-cell Lymphoma

Corvus Pharmaceuticals

Lymphoma, Large-Cell, Anaplastic; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell, Cutaneous; Lymphoma, T-Cell, Peripheral

Inici: 03/05/2019
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

An Open-Label, Phase I Clinical Study to Evaluate the Safety, Tolerability, PK/PD and Preliminary Efficacy of HBM4003 in Combination With Toripalimab ...

Harbour BioMed Therapeutics/Harbour BioMed (Guangzhou) Co.

Carcinoma, Hepatocellular; Liver Cancer; Liver Neoplasms; Neoplasms; Neoplasms, Unknown Primary

Inici: 15/12/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I, Open-Label, Multicenter, Dose Escalation Study of PRT2527 in Patients With Advanced Solid Tumors

Prelude Therapeutics

Breast Neoplasms; Fibrosarcoma; Leiomyosarcoma; Liposarcoma; Neoplasms; Neoplasms, Unknown Primary; Prostatic Neoplasms; Rhabdomyosarcoma; Sarcoma; Soft Tissue Neoplasms; Soft Tissue Sarcoma; Synovial Sarcoma; Triple Negative Breast Neoplasms

Inici: 14/02/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

An Observational Long-term Safety and Efficacy Follow-up Study After Ex-vivo Gene Therapy With BIVV003 in Participants With Severe Sickle Cell Disease...

Sanofi/Bioverativ

Anemia, Sickle Cell; beta-Thalassemia; Beta-Thalassemia; Lymphatic Diseases; Sickle Cell Anemia; Sickle Cell Trait; Thalassemia

Inici: 21/12/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase 1 Study of SPI-62+Prednisolone for the Treatment of Polymyalgia Rheumatica

Sparrow Pharmaceuticals

Polymyalgia Rheumatica

Inici: 01/01/1900
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Multicenter, Open-label, Phase I Study Evaluating the Safety and Tolerability of HMPL-760 in Patients With Previously Treated Chronic Lymphocytic Le...

Hutchmed {Hutchison MediPharma}

Chronic Lymphocytic Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Waldens??????????????????????

Inici: 15/02/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase 1, Randomized, Placebo-controlled, Double-blind, Single Ascending Dose Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmac...

Neuracle Science

Alzheimer Disease; Amyotrophic lateral sclerosis; Amyotrophic Lateral Sclerosis; Motor Neuron Disease; Neurodegenerative Diseases; Parkinson Disease

Inici: 04/11/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I Study of BEY1107G in Patients with Glioblastoma

BeyondBio Inc.

Glioblastoma

Inici: 01/01/1900
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I Dose-Finding Clinical Trial With Expansion Cohort Evaluating CC-486 in Patients With Relapsed/Refractory T-Cell Large Granular Lymphocytic L...

Bristol-Myers Squibb

Chronic Lymphocytic Leukemia; Leukemia; Leukemia, Large Granular Lymphocytic; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Lymphoid; Myelodysplastic Syndromes

Inici: 25/04/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase Ib Dose Finding Study Assessing Safety and Activity of [177Lu]Lu-DOTA-TATE in Newly Diagnosed Extensive Stage Small Cell Lung Cancer (ES-SCLC)...

Novartis

Carcinoma, Small Cell; Lung Neoplasms; Neuroendocrine Tumors; Small Cell Lung Carcinoma

Inici: 30/05/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase Ib Study Of The Combination Of CD47 Blockade With SIRP-Alpha FC Fusion Proteins (TTI-622) And Daratumumab Hyaluronidase-fihj For Patients With...

Memorial Sloan-Kettering Cancer Center Pfizer {Trillium Therapeutics {Stem Cell Therapeutics/Trillium Therapeutics}}

Multiple Myeloma; Neoplasms, Plasma Cell

Inici: 28/10/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

An Open-Label Phase I Clinical Study To Evaluate The Safety, Tolerability,Pharmacokinetics And Preliminary Efficacy Of HH-101 Injection As A Monothera...

Huahui Health

Bile Duct Neoplasms; Carcinoma, Non-Small-Cell Lung; Cholangiocarcinoma; Colorectal Neoplasms; Esophageal Cancer; Esophageal Neoplasms; Melanoma; Stomach Carcinoma; Stomach Neoplasms

Inici: 19/01/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I Clinical Study on the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Food Effects of CX1440 Capsules on the Pharmacokinetics o...

Hangzhou Aojin Biomedical Technology Co.

Chronic Lymphocytic Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Non-Hodgkin

Inici: 18/11/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Single-Arm, Multi-Center Phase I/IIa Clinical Study To Evaluate The Safety, Tolerability, Biodistribution Characteristics And Biological Effects Of ...

Shanghai Pharmaceuticals Holding Co. Immvira Co.

Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Hodgkin Disease; Hodgkin Lymphoma; Liver Cancer; Liver Neoplasms; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Non-Hodgkin; Mesothelioma; Neoplasms, Mesothelial; Neoplasms, Unknown Primary

Inici: 21/02/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Phase 1, Dose-Escalating, Double-Blind, Randomized, Comparator-Controlled Trial of the Safety, Tolerability, and Immunogenicity of the Transmission-Bl...

National Institutes of Health/National Institute of Allergy and Infectious Diseases (Other Hospital/Academic/Medical Center) Novavax

Malaria; Malaria, Falciparum; Rabies; Virus Diseases

Inici: 22/10/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of Recombinant Humanized Anti-PCSK9 Monoclona...

Shanghai Junshi Biosciences Co.

Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Kidney Neoplasms; Liver Cancer; Liver Neoplasms; Neoplasms; Neoplasms, Unknown Primary; Renal Cancer; Urethral Neoplasms; Urinary Bladder Neoplasms; Wilms Tumor

Inici: 23/12/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I Trial to Assess Safety, Tolerability and Anti-tumor Activity of Autologous T Cell Modified Chimeric Antigen Receptor (CAR) (CCT301-38) in Pa...

(Other Hospital/Academic/Medical Center) Shanghai PerHum Therapeutics Co. {Shanghai Sinobioway Sunterra Biotechnology Co.} (Sinobioway Group, Sunterra Capital and F1 Oncology joint venture)

Fibrosarcoma; Leiomyosarcoma; Liposarcoma; Rhabdomyosarcoma; Sarcoma; Soft Tissue Neoplasms; Soft Tissue Sarcoma; Synovial Sarcoma

Inici: 30/12/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I Study Of TAS-116 (Pimitespib) In Combination With Imatinib In Patients With Advanced Gastrointestinal Stromal Tumor (GIST) (CHAPTER-GIST-101...

Otsuka Holdings/Taiho Pharmaceutical

Gastrointestinal Stromal Tumors

Inici: 01/12/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Study to Evaluate the Safety and Clinical Activity of Allogeneic CAR-T Targeting CD7 in Patients With Refractory or Relapsed T Cell Malignancies

(Other Hospital/Academic/Medical Center) Fundamenta Therapeutics

Lymphoma; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell; Lymphoma, T-Cell, Cutaneous; Lymphoma, T-Cell, Peripheral; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Inici: 22/01/2020
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I/II Trial of Maintenance Fedratinib to Prevent Post-Transplant Relapse in Myeloproliferative Neoplasms

Bristol-Myers Squibb H. Lee Moffitt Cancer Center and Research Institute

Myeloproliferative Disorders; Neoplasms; Polycythemia Vera; Thrombocythemia, Essential

Inici: 14/03/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Phase I clinical study to evaluate the safety and tolerability, pharmacokinetics and preliminary efficacy of humanized Claudin18.2 monoclonal antibody...

Zhejiang Doer Biologics Corporation

Esophageal Neoplasms; Neoplasms, Unknown Primary; Pancreatic Neoplasms; Stomach Neoplasms

Inici: 19/04/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Safety and Efficacy Evaluation of IM83 CAR-T Cells for Patients Wirh Advanced Liver Tumors

Beijing Immunochina Medical Science & Technology Co.

Carcinoma, Hepatocellular; Liver Cancer; Liver Neoplasms

Inici: 24/08/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase 1/2 Open-Label, Dose-Escalation Study to Determine the Safety Tolerability & Efficacy of BMN 331 an AAV Vector-Mediated Gene Transfer of Human...

BioMarin

Angioedema; Angioedemas, Hereditary

Inici: 15/02/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase IB/IIA Trial Of CEND-1 In Combination With Neoadjuvant FOLFIRINOX Based Therapies In Pancreatic, Colon And Appendiceal Cancers (CENDIFOX)

University of Kansas Cend Therapeutics

Colorectal Neoplasms; Liver Neoplasms; Neoplasm Metastasis; Pancreatic Cancer; Pancreatic Neoplasms; Peritoneal Neoplasms

Inici: 16/11/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I Study to Evaluate the Safety, Tolerance and Efficacy of CRTE7A2-01 TCR-T Cell for HPV16 Positive Advanced Cervical, Anal, or Head and Neck C...

Corregene Biotechnology Co.

Anus Neoplasms; Head and Neck Neoplasms; Uterine Cervical Neoplasms

Inici: 28/06/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Mechanism of Resistance to GNC-038,a Tetra-specific T Cell Engager, in Relapsed and Refractory Diffuse Large B-cell Lymphoma

(Other Hospital/Academic/Medical Center) Biokin Pharmaceutical/Sichuan Baili Pharmaceutical Co.

Lymphoma; Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Non-Hodgkin

Inici: 25/04/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase 1 Open Label Study to Evaluate the Pharmacokinetics, Safety and Tolerability of ASP0367 in Participants With Renal Impairment Compared to Heal...

Astellas Pharma/Mitobridge

Muscular Dystrophies; Renal Insufficiency

Inici: 16/12/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

An Open Phase I Study To Evaluate The Safety, Tolerability, PK/PD And Preliminary Efficacy Of HBM4003 In Combination With Treprizumab In Patients With...

Harbour BioMed Therapeutics

Neoplasms; Neoplasms, Unknown Primary; Neuroendocrine Tumors

Inici: 04/01/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I Study of IRF4rx in Patients with Multiple Myeloma

Flamingo Therapeutics

Multiple Myeloma

Inici: 01/01/1900
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Phase I/IIa Study of Descartes-25 in Patients With Relapsed/Refractory Multiple Myeloma

Cartesian Therapeutics

Multiple Myeloma; Neoplasms, Plasma Cell; Recurrence

Inici: 25/11/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I, Open-Label, Dose Escalation of HBI-2376 in Patients With Advanced Malignant Solid Tumors Harboring KRAS or EGFR Mutations

HUYA Bioscience

Carcinoma, Non-Small-Cell Lung; Colonic Neoplasms; Colorectal Neoplasms; Neoplasms, Unknown Primary; Pancreatic Cancer; Pancreatic Neoplasms

Inici: 13/12/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I, Open-Label Study of the Safety, Tolerability and Preliminary Clinical Activity of Allogeneic Invariant Natural Killer T (iNKT) Cells (agenT...

Agenus/MiNK Therapeutics

Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Head and Neck Neoplasms; Liver Cancer; Liver Neoplasms; Multiple Myeloma; Neoplasms; Neoplasms, Unknown Primary

Inici: 28/01/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase Ib Dose Finding Study Assessing Safety and Activity of [177Lu]Lu-DOTA-TATE in Newly Diagnosed Glioblastoma in Combination With Radiotherapy Wi...

Novartis

Glioblastoma

Inici: 10/05/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I, Open-Label, Multicenter, Dose Escalation Study of PRT1419 Injection in Patients With Relapsed/Refractory Hematologic Malignancies

Prelude Therapeutics

Acute Myelocytic Leukemia; Hematologic Neoplasms; Leukemia; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Leukemia, Myelomonocytic, Juvenile; Myelodysplastic Syndromes; Myeloproliferative Disorders

Inici: 22/03/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

An Open-Label, Multi-Center, Phase I Study to Evaluate the Safety, Tolerability,Pharmacokinetic/Pharmacodynamics and Anti-tumor Activity of Tetra-spec...

Biokin Pharmaceutical/Sichuan Baili Pharmaceutical Co. Biokin Pharmaceutical/SystImmune

Acute Myelocytic Leukemia; Chronic Lymphocytic Leukemia; Hematologic Neoplasms; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Non-Hodgkin; Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lym?????

Inici: 15/12/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I, First in Human, Dose-Escalation Study of TORL-1-23 in Participants With Advanced Cancer

(Other Cooperative Group) TORL Biotherapeutics

Carcinoma, Endometrioid; Endometrial Neoplasms; Neoplasms, Unknown Primary; Ovarian Cancer; Ovarian Neoplasms

Inici: 17/11/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

To Evaluate The Exploratory Clinical Study of all Human Anti-PD-L1 Antibody Injection (LDP) Combined With Recombinant Anti EGFR Human Mouse Chimeric M...

(Other Hospital/Academic/Medical Center) Guilin Sanjin Pharmaceutical Co./Dragonboat Biopharmaceutical (Shanghai) Co.

Carcinoma, Endometrioid; Colorectal Neoplasms; Endometrial Neoplasms; Esophageal Cancer; Esophageal Neoplasms; Head and Neck Neoplasms; Neoplasms, Unknown Primary; Ovarian Cancer; Ovarian Neoplasms; Uterine Cervical Neoplasms

Inici: 01/02/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

An Open Label, Multicenter Phase Ib/II Clinical Study to Evaluate Efficacy , Safety and PK of HLX208 in Advanced Anaplastic Thyroid Cancer (ATC) With ...

Shanghai Henlius Biotech (Shanghai Fosun Pharmaceutical Co. and Henlius Biopharmaceuticals Co. joint venture)

Thyroid Carcinoma, Anaplastic; Thyroid Diseases; Thyroid Neoplasms

Inici: 10/12/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase Ib/II Trial of Lurbinectedin Plus Doxorubicin in Leiomyosarcoma

Massachusetts General Hospital Jazz Pharmaceuticals

Fibrosarcoma; Leiomyosarcoma; Liposarcoma; Rhabdomyosarcoma; Sarcoma; Soft Tissue Neoplasms; Soft Tissue Sarcoma; Synovial Sarcoma

Inici: 04/02/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

An Investigator-initiated Phase I Study of SELINEXOR in Combination With Bevacizumab and Atezolizumab in Newly Diagnosed Advanced Hepatocellular Carci...

H. Lee Moffitt Cancer Center and Research Institute Karyopharm Therapeutics

Carcinoma; Carcinoma, Hepatocellular; Liver Cancer; Liver Neoplasms

Inici: 03/11/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I Study of Gentulizumab in Patients with Hematologic Malignancies, Advanced Malignant Solid Tumors and Lymphomas

GeneScience Pharmaceuticals Co.

Hematologic Neoplasms; Hodgkin Disease; Hodgkin Lymphoma; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Non-Hodgkin; Neoplasms, Unknown Primary

Inici: 01/01/1900
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I Study of JRF101c in Patients with Ovarian Cancer

Chengdu Jinrui Foundation Biotech Co.

Ovarian Cancer; Ovarian Neoplasms

Inici: 01/01/1900
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I Study of JRF101b in Patients with Medulloblastoma

Chengdu Jinrui Foundation Biotech Co.

Medulloblastoma

Inici: 01/01/1900
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Anti-tumor Activity of IPG7236 Administered Orally as a Single...

Immunophage Biotech Co.

Breast Neoplasms; Carcinoma, Renal Cell; Head and Neck Neoplasms; Kidney Neoplasms; Melanoma; Neoplasms, Unknown Primary; Renal Cancer; Unspecified; Wilms Tumor

Inici: 15/11/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase 1, 2-Part, Single Ascending Dose, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety, Tolerability, Pharmacokinetics, a...

Lundbeck Aprilbio

Neuromyelitis Optica; Unspecified

Inici: 18/03/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Study of CD19/BCMA Chimeric Antigen Receptor T Cells Therapy for Patients With Refractory Immune Nephritis

(Other Hospital/Academic/Medical Center) Yake Biotechnology

Autoimmune Diseases; Lupus Nephritis; Nephritis; Systemic Lupus Erythematosus

Inici: 20/10/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Study of CD19/BCMA Chimeric Antigen Receptor T Cells Therapy for Patients With Refractory Sjogren''s Syndrome

(Other Hospital/Academic/Medical Center) Yake Biotechnology

Autoimmune Diseases; Sjogren''s Syndrome; Syndrome

Inici: 05/11/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Study of CD19/BCMA Chimeric Antigen Receptor T Cells Therapy for Patients With Refractory Scleroderma

(Other Hospital/Academic/Medical Center) Yake Biotechnology

Autoimmune Diseases; Scleroderma, Diffuse; Scleroderma, Localized; Scleroderma, Systemic; Systemic Scleroderma

Inici: 08/10/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I Trial of ProAgio, an Anti- avß3 Integrin Cytotoxin, for Previously Treated Advanced Pancreatic Cancer and Other Solid Tumor Malignancies

National Institutes of Health/National Cancer Institute ProDa BioTech

Neoplasms; Neoplasms, Unknown Primary; Pancreatic Cancer; Pancreatic Neoplasms

Inici: 29/10/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Study of Hydroxychloroquine and Chlorphenesin Carbamate in Combination With mFOLFIRINOX in Inoperable Locally Advanced or Metastatic Pancreatic Canc...

Asan Medical Center CytoGen, Inc. Oncocross

Pancreatic Cancer; Pancreatic Neoplasms

Inici: 30/11/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A phase 1 study of BIO 017 for Angelman Syndrome

Biom Therapeutics

Angelman Syndrome

Inici: 01/01/1900
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I Study of XmAb968 in Patients with T-cell Acute Lymphoblastic Leukaemia (T-ALL), Acute Myeloid Leukaemia (AML), T-cell Lymphoblastic Lymphoma...

Xencor

Acute Myelocytic Leukemia; Leukemia, Myeloid, Acute; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Non-Hodgkin; Precursor Cell Lymphoblastic Leukemia-Lymphoma

Inici: 01/01/1900
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase 0 ''Trigger'' Trial of Niraparib in Newly-diagnosed Glioblastoma and Recurrent IDH1/2(+) ATRX Mutant Glioma

GlaxoSmithKline University of California, San Francisco (Other Hospital/Academic/Medical Center)

Glioblastoma; Glioma

Inici: 29/10/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Phase I Study of MEM-288 Oncolytic Virus in Solid Tumors Including Non-Small Cell Lung Cancer (NSCLC)

H. Lee Moffitt Cancer Center and Research Institute Duke Comprehensive Cancer Center Memgen

Breast Neoplasms; Carcinoma; Carcinoma, Merkel Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Head and Neck Neoplasms; Lung Neoplasms; Melanoma; Neuroendocrine Tumors; Pancreatic Cancer; Pancreatic Neoplasms; Triple Negative Breast Neopla???

Inici: 23/02/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

An Exploratory Study On The Treatment Of Hematological Malignancies With IMM01 For Injection

ImmuneOnco Biopharmaceuticals (Shanghai) Co.

Acute Myelocytic Leukemia; Hodgkin Disease; Hodgkin Lymphoma; Leukemia, Myeloid, Acute; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Non-Hodgkin; Multiple Myeloma; Myelodysplastic Syndromes

Inici: 18/10/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I/IIa Open Label Multicenter, Non-Randomized, Trial to Assess the Safety and Efficacy of CYNK-001in Combination With Recombinant Human Interle...

Celularity

Astrocytoma; Glioblastoma

Inici: 08/03/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I Open-label, Single Arm Study Targeting Glypican-3 (GPC3) Chimeric Antigen Receptor Modified T Cells (CAR-T) for Treatment of Advanced Hepato...

(Other Hospital/Academic/Medical Center) Shanghai Pharmaceuticals Holding Co.

Carcinoma; Carcinoma, Hepatocellular; Liver Cancer; Liver Neoplasms

Inici: 29/10/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Steady-State Bioequivalence Study Of Olaparib Tablets In Patients With Ovarian Cancer: Multi-Center, Postprandial, Random, Open, Two-Period, Two-Cross...

Sichuan Kelun Pharmaceutical Co.

Fallopian Tube Neoplasms; Ovarian Cancer; Ovarian Neoplasms; Peritoneal Neoplasms

Inici: 15/11/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

An Open Label Phase I PET Imaging Study to Investigate the Biodistribution and Tumor Uptake of [89Zr]Zr-BI 765063 in Patients With Head and Neck Squam...

Boehringer Ingelheim

Carcinoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Head and Neck Neoplasms; Lung Neoplasms; Melanoma; Squamous Cell Carcinoma of Head and Neck

Inici: 16/11/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I trial of RG6315 for scleroderma

Roche

Systemic Scleroderma

Inici: 15/08/2020
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Randomized, Double-Blinded, Placebo-Controlled, MultipleAscending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodyn...

Sumitomo Dainippon Pharma/Sumitovant Biopharma/Altavant Sciences {Roivant Sciences/Altavant Sciences}

Hypertension; Hypertension, Pulmonary; Unspecified

Inici: 01/10/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I Dose-Escalation Study To Evaluate The Safety, Tolerability And Pharmacokinetics Of ACT001 In Patients With Advanced Solid Tumors (Part B).

Tianjin Accendatech Technology Co./Accendatech AU Pty

Glioblastoma

Inici: 15/04/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I/II, Closed Label, Randomized, Pilot Study for the Safety and Efficacy of TolaSure Gel, 5% w/w Targeting Aggregated Mutant Keratin in Severe ...

BioMendics

Epidermolysis Bullosa; Epidermolysis Bullosa Simplex

Inici: 02/03/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Phase I Clinical Trial evaluating the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of SKB315 for Injection in Patients with Advance...

Sichuan Kelun Pharmaceutical Co./Sichuan Kelun Botai Biopharmaceutical Co.

Esophageal Cancer; Esophageal Neoplasms; Neoplasms; Neoplasms, Unknown Primary; Pancreatic Cancer; Pancreatic Neoplasms; Stomach Carcinoma; Stomach Neoplasms

Inici: 16/03/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Phase I Trial of Human Chimeric Antigen Receptor Modified T Cells (huCART-meso) Administered in Combination With VCN-01 in Patients With Pancreatic an...

University of Pennsylvania VCN Biosciences

Carcinoma, Ovarian Epithelial; Ovarian Cancer; Ovarian Neoplasms; Pancreatic Cancer; Pancreatic Neoplasms

Inici: 17/02/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Phase I, Open-Label, Multicentre, Dose-Escalation Study to Evaluate the Safety and Pharmacokinetics of A Single Intravenous PPMX-T003 in Polycythemia ...

Perseus Proteomics Inc.

Myeloproliferative Disorders; Polycythemia; Polycythemia Vera

Inici: 01/09/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Pulmonary Gas Exchange and Neuro-sensory Abnormalities in Patients With Idiopathic Pulmonary Fibrosis and Mild Mechanical Restriction. Implications fo...

Boehringer Ingelheim (Other Hospital/Academic/Medical Center)

Fibrosis; Idiopathic Pulmonary Fibrosis; Pulmonary Fibrosis

Inici: 21/04/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Phase I/II Trial of Radiotherapy in Combination With Atezolizumab Prior to Surgical Resection for HPV-unrelated Squamous Cell Carcinoma of the Head an...

National Institutes of Health/National Cancer Institute University of Colorado Roche/Genentech

Carcinoma; Carcinoma, Squamous Cell; Head and Neck Neoplasms; Squamous Cell Carcinoma of Head and Neck

Inici: 02/11/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Application of ctDNA Assay in the Neoadjuvant and Adjuvant Chemotherapy Setting in Patients With Resectable Pancreatic Cancer

University of Oklahoma Natera

Pancreatic Cancer; Pancreatic Neoplasms

Inici: 25/05/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I Dose Escalation Study of ZN-d5 Monotherapy in Chinese Subjects With Non-Hodgkin Lymphoma

Thermo Fisher Scientific/Patheon Zentera Therapeutics/Zentera Therapeutics HK

Lymphoma; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin

Inici: 21/10/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Phase I/IIa clinical trial to evaluate the safety, tolerability, pharmacokinetic characteristics and preliminary efficacy of CDK9 inhibitor YK-2168 in...

Nanjing Yoko Pharmaceutical Group Co./Nanjing Yoko Bio-Medical Research Co.

Hodgkin Disease; Hodgkin Lymphoma; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Non-Hodgkin; Neoplasms, Unknown Primary

Inici: 19/01/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Phase I Trial of Anti-CD19 Universal CAR-T Therapy For Relapsed/Refractory Diffuse Large B-Cell Lymphoma

(Other Hospital/Academic/Medical Center) Sunnycell Therapeutics

Lymphoma, Large B-Cell, Diffuse; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Non-Hodgkin

Inici: 01/03/2019
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I Trial in Anti-BCMA CAR-T

The Pregene (Shen Zhen) Biotechnology Company

Multiple Myeloma

Inici: 01/01/1900
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Long-Term Follow-up of Fabry Disease Subjects Who Were Treated With ST-920, an AAV2/6 Human Alpha Galactosidase A Gene Therapy

Sangamo Therapeutics/TxCell

Fabry Disease

Inici: 16/08/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A First-In-Human, Multicenter, Open-Label, Phase I Dose Escalation Study To Evaluate The Safety, Tolerability And Pharmacokinetics Of YH004 As A Singl...

Biocytogen/Eucure (Beijing) Biopharma Co.

Lymphoma, Large-Cell, Anaplastic; Lymphoma, Non-Hodgkin; Neoplasms, Unknown Primary; Unspecified

Inici: 07/12/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase Ib Study to Evaluate the Safety, Tolerability, and Pharmacokinetics/Pharmacodynamics of MK-0482 in Participants With Relapsed or Refractory Ac...

Merck & Co./Merck Sharp & Dohme (MSD)

Acute Myelocytic Leukemia; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute

Inici: 26/09/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

An Open-Label Multicenter Phase Ib Study of AN0025 in Combination With Chemoradiotherapy in Patients With Locally Advanced/Locally Recurrent Esophagea...

Adlai Nortye Biopharma Co.

Esophageal Cancer; Esophageal Neoplasms; Stomach Carcinoma; Stomach Neoplasms

Inici: 23/12/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

An Open, Single-Arm, Multi-Center Phase II Clinical Study To Evaluate The Efficacy And Safety Of Recombinant Anti-PD-1 Humanized Monoclonal Antibody I...

3SBio/Sunshine Guojian Pharmaceutical (Shanghai) Co.

Fibrosarcoma; Leiomyosarcoma; Liposarcoma; Rhabdomyosarcoma; Sarcoma; Soft Tissue Neoplasms; Soft Tissue Sarcoma; Synovial Sarcoma

Inici: 21/02/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Bioequivalence Study with the Improved Version of dasatinib at a Lower Dose Strength Compared with Sprycel in Patients with Acute Lymphoblastic Leuk...

Xspray

Chronic Myeloid Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Precursor Cell Lymphoblastic Leukemia-Lymphoma

Inici: 01/01/1900
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Single-arm, Multicenter, Phase Ib/II Clinical Study of Docetaxel for Injection (Albumin-bound) in Combination With Nivolumab in Patients With Recurr...

CSPC Pharmaceutical Group Co./CSPC ZhongQi Pharmaceutical Technology Co.

Carcinoma; Carcinoma, Squamous Cell; Head and Neck Neoplasms; Squamous Cell Carcinoma of Head and Neck

Inici: 01/02/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Safety And Efficacy Of Radiotherapy Combined With CAR-T Immunotherapy For High-Risk Lymphoid Malignancies

(Other Hospital/Academic/Medical Center) Hunan Siweikang Therapeutics Co.

Hodgkin Disease; Hodgkin Lymphoma; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Non-Hodgkin; Multiple Myeloma

Inici: 11/06/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Multi-center, Phase I, Open Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, Immunogenicity and Efficacy of ...

Shandong Taize Huikang Biological Medicine Co. Shandong TheraWisdom Biopharma Co.

Lymphoma, Large-Cell, Anaplastic; Lymphoma, Non-Hodgkin; Neoplasms; Neoplasms, Unknown Primary

Inici: 08/03/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I Study of Vyxeos Plus Gilteritinib in Relapsed or Refractory, FLT3-Mutated Acute Myeloid Leukemia

H. Lee Moffitt Cancer Center and Research Institute Jazz Pharmaceuticals

Acute Myelocytic Leukemia; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute

Inici: 23/08/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Multi-center, Phase Ib/IIa Clinical Trial to Evaluate the Tolerability, PK and Efficacy of ZSP1603 in Patients With Idiopathic Pulmonary Fibrosis

Guangdong Zhongsheng Pharmaceutical Co./Guangdong Raynovent Biotech Co.

Fibrosis; Idiopathic Pulmonary Fibrosis; Pulmonary Fibrosis

Inici: 12/10/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Randomized, Double-blind, Placebo-controlled Study of the Safety, Tolerability, and Pharmacokinetics of Single Ascending Dosed of HSK31858 in Health...

Haisco Pharmaceutical Group Co.

Bronchiectasis; Unspecified

Inici: 28/10/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Pilot Study of the Safety and Efficacy of Anti-FLT3 Chimeric Antigen Receptor Engineered T-Cells in the Treatment of Relapsed or Refractory Acute Myel...

(Other Hospital/Academic/Medical Center) PersonGen BioTherapeutics (Suzhou) Co.

Acute Myelocytic Leukemia; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute

Inici: 19/10/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I/II Study of AMAX-126 in Patients with Glioblastoma

Aveta Biomics

Glioblastoma

Inici: 01/01/1900
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A phase Ib Clinical Study Evaluating the safety, Pharmacokinetics and Preliminary Efficacy of QL1706 injection Combined with Bevacizumab injection in ...

Qilu Pharmaceutical Co.

Carcinoma, Hepatocellular; Liver Cancer; Liver Neoplasms

Inici: 01/07/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

TAA05 Cell Injection in the Treatment of Recurrent / Refractory Acute Myeloid Leukemia

(Other Hospital/Academic/Medical Center) PersonGen BioTherapeutics (Suzhou) Co.

Acute Myelocytic Leukemia; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute

Inici: 01/07/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Randomized, Open Label, Multi-Center, Two-Treatment, Three Period, Three-Sequence, Reference Replicate, Multiple Dose, Steady-State, Bioequivalence ...

Natco Pharma

Breast Neoplasms; Fallopian Tube Neoplasms; Ovarian Cancer; Ovarian Neoplasms; Peritoneal Neoplasms; Prostatic Neoplasms

Inici: 16/08/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I Study of Venetoclax in Combination With Inotuzumab Ozogamicin for B-cell Acute Lymphoblastic Leukemia (B-ALL)

Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute AbbVie

Chronic Myeloid Leukemia; Leukemia; Leukemia, Lymphoid; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lymphoma, B-Cell; Precursor Cell Lymphoblastic Leukemia-Lymphoma

Inici: 24/09/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Multicentric Open Label Randomized Two Period Two Treatment Two Sequence Crossover Multiple Dose Steady State Bioequivalence Study Of Sunitinib Mala...

Eugia Pharma Specialities (Aurobindo Pharma and Celon Laboratories joint venture)

Carcinoma, Renal Cell; Kidney Neoplasms; Renal Cancer; Wilms Tumor

Inici: 15/04/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I Study Evaluating the Safety, Tolerability, And Pharmacokinetics of IMGN853 in Chinese Adult Patients with Folate Receptor 1 (FOLR1) Positive...

ImmunoGen Huadong Medicine Co./Hangzhou Zhongmei Huadong Pharmaceutical Co. Almac Group/Almac Clinical Services BSP Pharmaceuticals

Carcinoma, Endometrioid; Carcinoma, Non-Small-Cell Lung; Endometrial Neoplasms; Fallopian Tube Neoplasms; Neoplasms, Unknown Primary; Ovarian Cancer; Ovarian Neoplasms; Peritoneal Neoplasms

Inici: 22/11/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Phase Ib Clinical Trial to Evaluate the Safety and Efficacy of AL2846 Capsules in Chinese Patients With Type I Neurofibromatosis (Neurofibromatosis an...

Sino Biopharmaceutical/Chia Tai Tianqing Pharmaceutical Group Co.

Fibrosarcoma; Leiomyosarcoma; Liposarcoma; Nerve Sheath Neoplasms; Neurofibroma; Neurofibromatoses; Neurofibromatosis 1; Neurofibrosarcoma; Rhabdomyosarcoma; Sarcoma; Soft Tissue Neoplasms; Soft Tissue Sarcoma; Synovial Sarcoma

Inici: 31/08/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Phase I Study to Evaluate the Safety and Effectiveness of Anti-BCMA CAR-NK Therapy in Relapsed or Refractory Multiple Myeloma

Sichuan Kelun Pharmaceutical Co. Xinqiao Hospital of Chongqing

Multiple Myeloma; Neoplasms, Plasma Cell

Inici: 01/10/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Phase I Study to Evaluate the Safety and Effectiveness of Anti-CD33 CAR NK Cell Therapy in Relapsed/Refractory Acute Myeloid Leukemia

Sichuan Kelun Pharmaceutical Co. Xinqiao Hospital of Chongqing

Acute Myelocytic Leukemia; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute

Inici: 23/12/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase Ib/II,Multi-center, Open, Multiple-dose Design to Evaluate the Safety,Tolerability and Efficacy of STSP-0601 for Injection in Patients With In...

Staidson (Beijing) Biopharmaceuticals Co.

Blood Coagulation Disorders; Hemophilia A; Hemophilia B; Hemostatic Disorders

Inici: 18/10/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Clinical Study of Chemotherapy Combined With Camrelizumab and Apatinib in First-line Treatment of Extensive Stage Small Cell Lung Cancer

(Other Hospital/Academic/Medical Center) Jiangsu Hengrui Pharmaceuticals Co.

Carcinoma, Small Cell; Lung Neoplasms; Neuroendocrine Tumors; Small Cell Lung Carcinoma

Inici: 27/01/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Novel Combination of Belantamab Mafodotin and Elotuzumab to Enhance Therapeutic Efficacy in Multiple Myeloma

GlaxoSmithKline Yale University

Multiple Myeloma; Neoplasms, Plasma Cell

Inici: 21/02/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Randomized, Open, Two-cycle, Two-Crossover Bioequivalence Pilot Study of Irinotecan Hydrochloride Liposomal Injection (43mg/10mL) in Patients With A...

Zhejiang Shenzhou Pharmaceutical Co.

Pancreatic Cancer; Pancreatic Neoplasms

Inici: 02/12/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I/II Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Initial Efficacy of Recombinant Humanized Anti-BTLA Monoclonal Antibody ...

Shanghai Junshi Biosciences Co. Suzhou Zhonghe Biopharmaceutical

Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Lung Neoplasms; Neuroendocrine Tumors; Small Cell Lung Carcinoma

Inici: 27/08/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

An Open-label, Phase Ib, Dose Escalation and Expansion Study to Evaluate the Safety, Tolerability, Maximum Tolerated or Administered Dose, Pharmacokin...

Bayer AG

Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Head and Neck Neoplasms; Kidney Neoplasms; Neoplasms, Unknown Primary; Renal Cancer; Unspecified; Urethral Neoplasms; Urinary Bladder Neoplasms; Wilms Tumor

Inici: 30/08/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I Open-Label Study of Genetically Engineered Oncolytic HSV-1 (C5252) Expressing IL-12 and Anti-PD-1 Antibody in Patients With Recurrent or Pro...

Immvira Co.

Glioblastoma; Neoplasms, Unknown Primary

Inici: 21/02/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

An Open-label, Multi-center Phase Ib/II Study to Evaluate the Tolerance and Efficacy of Mitoxantrone Hydrochloride Liposome Injection Combined With Cy...

CSPC Pharmaceutical Group Co./CSPC Zhongnuo Pharmaceutical (Shijiazhuang) Co.

Acute Myelocytic Leukemia; Leukemia, Myeloid, Acute

Inici: 08/11/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Study Evaluating the Safety, Tolerability, and Pharmacokinetics of LUCAR-20S in Patients With Relapsed/Refractory Diffuse Large B-Cell, Follicular, ...

(Other Hospital/Academic/Medical Center) Nanjing Legend Biotechnology Co.

Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin

Inici: 01/12/2020
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I clinical trial evaluating HD CD19 CAR-T treatments for invasive B-cell non-Hodgkin''s lymphoma patients that are difficult to treat or relap...

Huadao (Shanghai) Biopharma Co.

Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin

Inici: 24/08/2020
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Pharmacokinetic and Pharmacodynamic Study of AMX0035 in Patients With ALS

Amylyx Pharmaceuticals

Amyotrophic lateral sclerosis; Amyotrophic Lateral Sclerosis; Motor Neuron Disease; Unspecified

Inici: 05/08/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Phase IB/II of CPX-351 as Maintenance Therapy in AML Patients Ineligible for Bone Marrow Transplantation

National Institutes of Health/National Heart, Lung, and Blood Institute Jazz Pharmaceuticals Georgetown University

Acute Myelocytic Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute

Inici: 08/02/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Phase I Dose Escalation And Dose Expansion Study Of The Safety, Tolerability, Pharmacokinetic Characteristics And Preliminary Anti-Tumor Activity Of W...

Cisen Pharmaceutical Co.

Breast Neoplasms; Neoplasms, Unknown Primary; Ovarian Cancer; Ovarian Neoplasms

Inici: 07/12/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase Ib Study of Oral Decitabine/Cedazuridine as Maintenance Therapy Following Allogeneic Hematopoietic Cell Transplantation for Patients With Myel...

Otsuka Holdings/Taiho Pharmaceutical Massachusetts General Hospital

Leukemia; Leukemia, Myelomonocytic, Chronic; Leukemia, Myelomonocytic, Juvenile; Myelodysplastic Syndromes; Neoplasms; Preleukemia

Inici: 17/09/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Phase I Clinical Study of Safety & Efficacy of DC Vaccine and TMZ for the Treatment of Newly-diagnosed Glioblastoma After Surgery

(Other Hospital/Academic/Medical Center) Guangdong Zhongsheng Pharmaceutical Co.

Glioblastoma

Inici: 30/07/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Prospective, Open, Dose-escalation, Multi-center, Phase 1/2a Trial to Evaluate the Safety, Tolerability and to Explore the Efficacy of PN-101 in Pat...

Paean Biotechnology

Dermatomyositis; Dermatomyositis; Polymyositis

Inici: 15/12/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Phase Ib/II Trial of Anti-PD-1 Immunotherapy and Stereotactic Radiation in Patients With Recurrent Glioblastoma

Cedars-Sinai Medical Center Merck & Co./Merck Sharp & Dohme (MSD)

Glioblastoma

Inici: 09/12/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

To Evaluate the Safety and Efficacy of LY011 Cell Injection (Targeting CLDN 18.2 Chimeric Antigen Receptor T Cells) in the Treatment of Advanced Gastr...

(Other Hospital/Academic/Medical Center) Shanghai Longyao Biotechnology

Adenocarcinoma; Esophageal Cancer; Esophageal Neoplasms; Stomach Carcinoma; Stomach Neoplasms

Inici: 26/07/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I, Open-Label, Dose-Escalation and Dose-Expansion Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Antitumor Activity of ADCT...

Auven Therapeutics/ADC Therapeutics

Bile Duct Neoplasms; Breast Neoplasms; Carcinoma, Renal Cell; Cholangiocarcinoma; Fallopian Tube Neoplasms; Kidney Neoplasms; Neoplasms; Neoplasms, Unknown Primary; Neuroendocrine Tumors; Ovarian Cancer; Ovarian Neoplasms; Prostatic Neoplasms; Renal Cance??????????????

Inici: 09/09/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I, Multicenter Study to Evaluate the Safety, Tolerability, and Efficacy of LCAR-T2C CAR-T Cells in Relapsed or Refractory CD4+ T Lymphocyte Tu...

(Other Hospital/Academic/Medical Center) Nanjing Legend Biotechnology Co.

Leukemia, T-Cell; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell, Cutaneous; Lymphoma, T-Cell, Peripheral; Precursor Cell Lymphoblastic Leukemia-Lymphoma

Inici: 15/06/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

An Open-Label, Dose Escalation/Dose Exploration, Phase I Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Single/Multiple Infusion o...

(Other Hospital/Academic/Medical Center) CARsgen Therapeutics

Carcinoma; Carcinoma, Hepatocellular; Liver Cancer; Liver Neoplasms

Inici: 05/08/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Pharmacokinetic and Pharmacodynamic Study of DZ-002 in Patients With Advanced Solid Malignancies or Lymphoma

Da Zen Theranostics

Hodgkin Disease; Hodgkin Lymphoma; Lymphoma; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Non-Hodgkin; Neoplasms, Unknown Primary; Pancreatic Cancer; Pancreatic Neoplasms; Prostatic Neoplasms

Inici: 12/08/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase Ib/II Single-arm Study Evaluating the Safety and Efficacy of Combined Immunotherapy With mFOLFOX6, Bevacizumab and Atezolizumab in Advanced-st...

(Other Hospital/Academic/Medical Center) Roche {F. Hoffmann-La Roche}

Bile Duct Neoplasms; Biliary Tract Neoplasms; Cholangiocarcinoma

Inici: 01/10/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Clinical Trial of a 3-dose, 28-Day Regimen of PfSPZ Vaccine in Healthy, Malaria-Naïve, Adult Subjects to Determine Safety, Tolerability and Efficacy...

Fred Hutchinson Cancer Research Center Sanaria

Malaria

Inici: 27/09/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Study of CLDN18.2 Chimeric Antigen Receptor T Cells in the Treatment of Advanced Pancreatic Cancer

Shanghai Longyao Biotechnology

Pancreatic Cancer; Pancreatic Neoplasms

Inici: 19/07/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

RENEW: Pilot Study of Feasibility of CMV RNA-Pulsed Dendritic Cells Vaccines for the Treatment of Newly Diagnosed Glioblastoma Patients.

University of Florida - Gainesville Immunomic Therapeutics

Glioblastoma

Inici: 30/11/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I Study of Uproleselan Combined With Azacitidine and Venetoclax for the Treatment of Older or Unfit Patients With Treatment Naive Acute Myeloi...

National Institutes of Health/National Cancer Institute GlycoMimetics

Acute Myelocytic Leukemia; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute

Inici: 02/07/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

An Open, Dose-Escalated Phase I Clinical Trial To Evaluate The Safety Of YS-ON-001 In Subjects With Advanced Breast Cancer, Advanced Lung Cancer, Adva...

YiSheng Biopharma

Breast Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Liver Cancer; Liver Neoplasms; Melanoma

Inici: 31/12/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase Ia Clinical Study to Evaluate Safety,Tolerability, Pharmacokinetics and Pharmacodynamics of Recombinant Anti-CD20 Humanized Monoclonal Antibod...

Shanghai Pharmaceuticals Holding Co.

Lymphoma, B-Cell, Marginal Zone; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Waldenstrom Macroglobulinemia

Inici: 16/11/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I Clinical Study of Mitoxantrone Hydrochloride Liposome Injection in Combination With Bortezomib and Dexamethasone in Patients With Relapsed o...

CSPC Pharmaceutical Group Co./CSPC Zhongnuo Pharmaceutical (Shijiazhuang) Co.

Multiple Myeloma; Neoplasms, Plasma Cell

Inici: 20/10/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase IB/llA, Open-label Study of the Safety, Pharmacokinetics, and Pharmacodynamics of Fosciclopirox Alone and In Combination With Cytarabine in Pa...

CicloMed

Acute Myelocytic Leukemia; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute

Inici: 27/08/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase Ib, Open-label, Parallel Group, Multiple-dose Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Oral Decitabine and Cedazuri...

Otsuka Holdings/Otsuka Pharmaceutical/Astex Pharmaceuticals

Acute Myelocytic Leukemia; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Neoplasms, Unknown Primary

Inici: 15/12/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase Ib, Open-label, Parallel Group, Multiple-dose Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Oral Decitabine and Cedazuri...

Otsuka Holdings/Otsuka Pharmaceutical/Astex Pharmaceuticals {SuperGen}

Acute Myelocytic Leukemia; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Neoplasms, Unknown Primary

Inici: 25/01/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Intratumor CpG-ODN Boosters Immune Killing Against in Situ Tumor Antigen Released by Interventional Approaches for Advanced Solid Tumors

(Other Hospital/Academic/Medical Center) Guangdong Zhaotai InVivo Biomedicine Co.

Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Liver Cancer; Liver Neoplasms; Neoplasms, Unknown Primary

Inici: 01/03/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I Clinical Study of TQB3820 tablets for the Treatment of Patients with Malignant hematological tumor

Sino Biopharmaceutical/Chia Tai Tianqing Pharmaceutical Group Co.

Chronic Lymphocytic Leukemia; Hematologic Neoplasms; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Non-Hodgkin; Multiple Myeloma; Neoplasms

Inici: 25/08/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Clinical Study of Intratumoral Injection of CAR-T Cells in the Treatment of Advanced Liver Tumors

Beijing Immunochina Medical Science & Technology Co.

Bile Duct Neoplasms; Carcinoma, Hepatocellular; Cholangiocarcinoma; Cholangiocarcinoma; Liver Cancer; Liver Neoplasms

Inici: 01/01/2019
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Phase I/II Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Effectiveness of MRX2843 Tablets in Patients With Relapsed/Refrac...

Betta Pharmaceuticals Co.

Acute Myelocytic Leukemia; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute

Inici: 27/10/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

ONO-7913-02: Multi-Center, Open-Label Phase I Study of ONO-7913 (Magrolimab) in Combination With Azacitidine in Patients With MDS

Ono Pharmaceutical

Myelodysplastic Syndromes

Inici: 22/06/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Personalized Vaccine for Patients With Recurrent Malignant Glioma: a Single-arm, Single-center, Open-labeled Study

(Other Hospital/Academic/Medical Center) Beijing Neoantigen Biotechnology Co.

Glioblastoma; Glioma

Inici: 29/06/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Single Arm, Open-label, Multicenter, Phase Ib Study of TQ05105 Tablets in Subjects With aGVHD

Sino Biopharmaceutical/Chia Tai Tianqing Pharmaceutical Group Co./Nanjing Shunxin Pharmaceutical Co.

Graft Rejection; Graft vs Host Disease; Stem Cell Transplantation; Unspecified

Inici: 28/06/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Multicenter Phase I, Open-Label Study of NB003 to Assess Safety, Tolerability, Pharmacokinetics and Efficacy in Patients With Advanced Malignancies

Ningbo NewBay Medical Technology Co.

Gastrointestinal Stromal Tumors; Neoplasms; Neoplasms, Unknown Primary

Inici: 06/08/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Non-gene Edited Anti-CD7 CAR T Cells for Relapsed/Refractory T Cell Malignances

(Other Hospital/Academic/Medical Center) iCell Gene Therapeutics/iCAR Bio Therapeutics

Leukemia, Lymphoid; Lymphoma; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Inici: 01/12/2020
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Study Evaluating The Safety, Pharmacokinetics And Anti-Tumor Activity Of NKD0901In Patients With EGFR-Positive Advanced Solid Tumor

(Other Hospital/Academic/Medical Center) Xiamen Nuokang Biotechnology Co.

Glioblastoma; Neoplasms, Unknown Primary

Inici: 01/09/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

An Open-Label, Single-Arm, Multi-Center Phase I Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of SHR-A1904 in Pa...

Jiangsu Hengrui Pharmaceuticals Co. {Jiangsu Hengrui Medicine}/Shanghai Hengrui Pharmaceutical {Shanghai Hengrui Pharmaceutical (Jiangsu Hengrui Medicine, HKG Science & Tech. JV)}

Pancreatic Cancer; Pancreatic Neoplasms

Inici: 06/08/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Multi-Center Phase I Study of Codrituzumab in Pediatric Patients With Relapsed or Refractory Glypican 3 (GPC3) Expressing Extra-cranial Solid Tumors...

Memorial Sloan-Kettering Cancer Center Roche/Chugai Pharmaceutical

Carcinoma, Hepatocellular; Liver Cancer; Liver Neoplasms; Neoplasms; Neoplasms, Unknown Primary; Neuroblastoma

Inici: 09/06/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Novel Use of Restasis (Cyclosporine Ophthalmic Emulsion 0.05%) on Application of PROSE Devices for Management of Patients With Ocular Surface Disease:...

(Other Hospital/Academic/Medical Center) AbbVie/Allergan {Allergan/Actavis {Actavis/Allergan}}

Dry Eye Syndromes; Graft Rejection; Graft vs Host Disease; Sjogren''s Syndrome; Unspecified

Inici: 15/07/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Single Group, Open-Label, Multicenter ,Phase ?b/? Clinical Trials of TQ05105 Tablet in Patients With Glucocorticoid Refractory and Dependent Moderat...

Sino Biopharmaceutical/Chia Tai Tianqing Pharmaceutical Group Co./Nanjing Shunxin Pharmaceutical Co.

Graft Rejection; Graft vs Host Disease

Inici: 21/06/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I Open-label Study of KPT-9274 in Patients With Relapsed and Refractory Acute Myeloid Leukemia

University of Colorado Karyopharm Therapeutics

Acute Myelocytic Leukemia; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute

Inici: 27/08/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I/II Study to Investigate the Efficacy and Safety of MS-553 in Subjects With Relapsed or Refractory Chronic Lymphocytic Leukemia/Small Lymphoc...

Shenzhen MingSight-Relin Pharmaceutical Co. (MingSight Pharmaceuticals and Shenzhen Relin Medicine joint venture)

Chronic Lymphocytic Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Non-Hodgkin

Inici: 28/04/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I Open-Label Dose Escalation and Expansion Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Preliminary Antitumor Activity of ...

Guangzhou Lupeng Pharmaceutical Co.

Lymphoma; Lymphoma, B-Cell; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Non-Hodgkin; Waldenstrom Macroglobulinemia

Inici: 06/07/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase Ib Study of Isatuximab, Velcade, and Dexamethasone in Patients With Multiple Myeloma and Severe KIDNEY Disease

Washington University School of Medicine Sanofi

Kidney Diseases; Multiple Myeloma; Neoplasms, Plasma Cell

Inici: 01/04/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Clinical Studiy of Safety and Preliminary Efficacy of EBV CAR T Cells in Patients with Relapsed/Refractory EBV Positive Lympohma

(Other Hospital/Academic/Medical Center) Guangzhou Bairui Biomedical Technology Co.

Lymphoma, Large-Cell, Anaplastic; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell, Peripheral

Inici: 31/05/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I/II Combination Study of NMS-03305293 and Temozolomide in Adult Patients With Recurrent Glioblastoma

Nerviano Medical Sciences

Glioblastoma

Inici: 01/12/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Single Arm, Open Label, Phase 1b/2 Study of Novel BET Inhibitor PLX51107 for Steroid-Refractory Acute GVHD

Ohio State University Daiichi Sankyo/Plexxikon

Graft Rejection; Graft vs Host Disease

Inici: 24/03/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Clinical trial of human umbilical cord-derived mesenchymal stem cells in the treatment of refractory acute hematopoietic stem cell transplantation and...

Tianjin Amcellgene Engineering Co.

Graft Rejection; Graft vs Host Disease

Inici: 31/12/2020
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Phase I clinical trial to evaluate the safety of freeze-dried human rabies vaccine (Vero cells) in Chinese healthy people aged 10 to 60

Guangzhou Realbenefitspot Pharmaceutical Co. Guangzhou Yinhe Yangguang Biological Products Co.

Rabies; Virus Diseases

Inici: 09/05/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Study to Evaluate the Tolerance, Safety, Pharmacokinetics and Preliminary Efficacy of HER2-targeted CAB-T (PM3002) in Patients with Advanced Solid T...

(Other Hospital/Academic/Medical Center) Hainan Kaibo Biological Technology Co.

Breast Neoplasms; Carcinoma, Renal Cell; Kidney Neoplasms; Neoplasms, Unknown Primary; Renal Cancer; Stomach Carcinoma; Stomach Neoplasms; Urethral Neoplasms; Urinary Bladder Neoplasms; Wilms Tumor

Inici: 07/06/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I/II Clinical Study of JS004, a Recombinant Humanized mAb Specific to B-and T-Lymphocyte Attenuator (BTLA), in Subjects With Head and Neck Can...

Shanghai Junshi Biosciences Co./TopAlliance Biosciences

Head and Neck Neoplasms; Nasopharyngeal Carcinoma

Inici: 12/05/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase Ib, Multi-center, Open-label Dose Escalation and Expansion Platform Study of VAY736 as Single Agent and in Combination With Select Antineoplas...

Novartis

Lymphoma; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin

Inici: 10/10/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I/II Trial of AK117 (Anti-CD47) in Patients With Higher-risk Myelodysplastic Syndrome

Akeso Biopharma

Myelodysplastic Syndromes; Preleukemia; Syndrome

Inici: 18/06/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Multicenter, Open-label, Phase Ib Study of Mitoxantrone Hydrochloride Liposome Injection in Subjects With Advanced Bone and Soft Tissue Sarcoma Who ...

CSPC Pharmaceutical Group Co./CSPC ZhongQi Pharmaceutical Technology Co.

Ewing Sarcoma; Fibrosarcoma; Leiomyosarcoma; Liposarcoma; Osteosarcoma; Rhabdomyosarcoma; Sarcoma; Soft Tissue Neoplasms; Soft Tissue Sarcoma; Synovial Sarcoma

Inici: 29/11/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

An Open-Label Pilot Study to Evaluate the Safety and Efficacy of DVX201 NK Cells in Patients With Relapsed or Refractory AML or High Risk MDS or High ...

(Other Hospital/Academic/Medical Center) Deverra Therapeutics

Acute Myelocytic Leukemia; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Myeloproliferative Disorders; Unspecified

Inici: 15/12/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A First-in-human, Open-label, Multiple Center Phase I Dose-Escalation Study to Evaluate Safety, Tolerability, Pharmacokinetic, Immunogenicity, and Pre...

Lunan Pharmaceutical Group Corporation/Shandong New Time Pharmaceutical Co.

Multiple Myeloma; Neoplasms, Plasma Cell

Inici: 30/07/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I and Expansion Cohort Study of Selinexor and Venetoclax in Combination With Chemotherapy in Pediatric and Young Adult Patients With Refractor...

(Other Cooperative Group) St. Jude Children''s Research Hospital AbbVie Karyopharm Therapeutics

Acute Disease; Acute Myelocytic Leukemia; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence

Inici: 15/11/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

DNV3 Injection Open and Multi-Site Phase I/IIa Clinical Trial Of Safety, Tolerance, Pharmacokinetics and Preliminary Efficacy in Patients with Advance...

Chinese Academy of Medical Sciences Zhejiang Shimai Pharmaceutical Co.

Hodgkin Disease; Hodgkin Lymphoma; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Non-Hodgkin; Neoplasms, Unknown Primary

Inici: 17/05/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase IB Study of Safety, Efficacy and Pharmacokinetic of Intravenously Administered Pelcitoclax (APG-1252) in Patients With Advanced Neuroendocrine...

Ascentage Pharma Group

Neuroendocrine Tumors

Inici: 21/01/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

An Open, Single-arm, Multi-center Phase I Clinical Study of Recombinant Human Thrombopoietin Mimetic Peptide-Fc Fusion Protein for Injection in the Tr...

Sino Biopharmaceutical/Beijing Tide Pharmaceutical Co.

Purpura, Thrombocytopenic, Idiopathic

Inici: 19/06/2019
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I Study of CT-2426 in Patients with Myelodysplastic syndrome, Glioma

Shouyao Holdings (Beijing) Co.

Glioblastoma; Myelodysplastic Syndromes

Inici: 01/01/1900
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Open-label, Multi-center Phase I Study to Evaluate the Safety, Tolerability, Pharmacokinetics/Pharmacodynamics and Efficacy of BR790 Monotherapy in ...

Qingfeng Pharmaceutical Group Co./Jiangxi Qingfeng Pharmaceutical Co.

Carcinoma, Non-Small-Cell Lung; Esophageal Cancer; Esophageal Neoplasms; Head and Neck Neoplasms; Neoplasms; Neoplasms, Unknown Primary

Inici: 28/07/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I Study of JAB-8263 in Patients with Myelofibrosis (MF) and Acute Myeloid Leukemia (AML)

Beijing Jacobio Pharmaceuticals Co.

Acute Myelocytic Leukemia; Leukemia, Myeloid, Acute; Myeloproliferative Disorders; Primary Myelofibrosis

Inici: 01/03/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase IB, Open-label, Global, Multicenter, Dose Determination Study to Evaluate Safety, Tolerability, and Preliminary Efficacy of CC-486 (ONUREG®) i...

Bristol-Myers Squibb/Celgene AbbVie

Acute Myelocytic Leukemia; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute

Inici: 01/12/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I Open-label, Dose Escalation Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of the FHND6091 in Su...

Jiangsu Chia Tai Fenghai Pharmaceutical Co. (CP Pharmaceutical Group and Jiangsu Provincial Agricultural Reclamation and Development Co., Ltd. joint venture)

Multiple Myeloma; Neoplasms, Plasma Cell

Inici: 22/12/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I/II Study Evaluating the Safety and the Efficacy of SMART101 Injection to Accelerate Immune Reconstitution After T Cell Depleted Allogeneic H...

Smart Immune

Acute Myelocytic Leukemia; Graft Rejection; Graft vs Host Disease; Leukemia; Leukemia, Myeloid, Acute; Precursor Cell Lymphoblastic Leukemia-Lymphoma

Inici: 09/12/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I Multi-Center, Open, Non-Randomized, Dose-Escalating Clinical Trial Of Intratumoral Administration Of Clostridium Gordonii Spores Freeze-Drie...

Shandong Xinchuang Biotechnology Co.

Ewing Sarcoma; Fibrosarcoma; Leiomyosarcoma; Liposarcoma; Melanoma; Neoplasms, Unknown Primary; Osteosarcoma; Rhabdomyosarcoma; Sarcoma; Soft Tissue Neoplasms; Soft Tissue Sarcoma; Synovial Sarcoma

Inici: 01/01/1900
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

An Open-label, Multi-centre, Phase I/II Study to Investigate the Safety, Tolerability, and Preliminary Efficacy of CN1 in Combination With CN401 in Ad...

Curon Biopharmaceutical/Curon Biopharmaceutical (Australia)

Lymphoma, Large-Cell, Anaplastic; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell, Cutaneous; Lymphoma, T-Cell, Peripheral; Neoplasms

Inici: 28/07/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Multi-center, Phase Ia/Ib, Open Clinical Study to Evaluate the Safety, Tolerability and Pharmacokinetics of TWP-101 in Patients With Advanced Melano...

Shandong TheraWisdom Biopharma Co.

Carcinoma; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Kidney Neoplasms; Melanoma; Renal Cancer; Urethral Neoplasms; Urinary Bladder Neoplasms; Wilms Tumor

Inici: 07/02/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

An Open Label Evaluation Phase I Trial of the Safety and Pharmacokinetics of MRX-2843 in Adolescents and Adults With Relapsed/Refractory Acute Myeloid...

Meryx

Acute Myelocytic Leukemia; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Precursor Cell Lymphoblastic Leukemia-Lymphoma

Inici: 12/04/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I Study of SYHA1817 in Patients with Gastric Carcinoma, Cancer of Biliary Duct, Squamous Cell Lung Carcinoma

CSPC Pharmaceutical Group Co.

Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Liver Cancer; Liver Neoplasms; Stomach Carcinoma; Stomach Neoplasms

Inici: 01/01/1900
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Clinical Study Of XNW5004 Tablets In Assessing Safety, Tolerability, Pharmacokinetics, Pharmacodynamics And Preliminary Efficacy In Patients With Rela...

Sinovent

Hodgkin Disease; Hodgkin Lymphoma; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Non-Hodgkin; Neoplasms, Unknown Primary

Inici: 27/07/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Non-Randomized, Open-Label, Adaptive, Single Center, Positron Emission Tomography (Pet) Study To Assess Distribution Of RO7248824 In The Central Ner...

Roche {F. Hoffmann-La Roche}

Angelman Syndrome

Inici: 29/04/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Phase I/II Study of Ipilimumab Plus Nivolumab (IPI-NIVO) Combined With Sacituzumab Govitecan (SG) as First-line Treatment for Cisplatin-ineligible Met...

Bristol-Myers Squibb H. Lee Moffitt Cancer Center and Research Institute Gilead Sciences

Carcinoma; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Kidney Neoplasms; Renal Cancer; Urethral Neoplasms; Urinary Bladder Neoplasms; Wilms Tumor

Inici: 30/04/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I, Multicenter, Open-label, Dose Finding Study of CC-96673 in Subjects With Relapsed or Refractory Non-Hodgkin''s Lymphoma

Bristol-Myers Squibb/Celgene

Lymphoma; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Non-Hodgkin

Inici: 20/01/2022
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Pilot Study of Neoadjuvant Stereotactic Beam Radiation Therapy Followed by Atezolizumab and Bevacizumab in Resectable Hepatocellular Carcinoma

Massachusetts General Hospital Roche/Genentech

Carcinoma; Carcinoma, Hepatocellular; Liver Cancer; Liver Neoplasms

Inici: 18/06/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Randomized, Open Label, Multi-Center, Two-Treatment, Two-Period, Two-Sequence, Two-Way Cross-Over, Multiple Dose, Steady-State Relative Bioavailabil...

Oncogen Pharma (Malaysia)

Carcinoma, Renal Cell; Kidney Neoplasms; Renal Cancer; Wilms Tumor

Inici: 08/04/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I/II Study of Acalabrutinib, Venetoclax, and Obinutuzumab in Patients With Relapsed/Refractory and Previously Untreated Mantle Cell Lymphoma

AstraZeneca Roche/Genentech

Lymphoma; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin

Inici: 02/07/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Phase I/II, Multicenter, First-In-Human, Dose Escalation and Dose Expansion Study of CPO107 Administered Intravenously to Patients With Advanced CD20-...

CSPC Pharmaceutical Group Co./Conjupro Biotherapeutics

Chronic Lymphocytic Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin

Inici: 15/12/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

IFx-Hu2.0 Expanded Access Program

Morphogenesis Inc.

Carcinoma; Carcinoma, Merkel Cell; Carcinoma, Squamous Cell; Melanoma; Neuroendocrine Tumors; Skin Neoplasms

Inici: 01/01/1900
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I Study of B006 in Patients with Lymphoma

Shanghai Pharmaceuticals Holding Co.

Hodgkin Disease; Hodgkin Lymphoma; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Non-Hodgkin

Inici: 01/01/1900
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Randomized, Open-label, Single-dose, Two-preparation, Two-sequence, Two-cycle Crossover, Bioequivalence Study of Doxorubicin Hydrochloride Liposome ...

(Other Hospital/Academic/Medical Center) China Medical System Holdings/Shenzhen Kangzhe Pharmaceutical Co.

Breast Neoplasms; Carcinoma, Ovarian Epithelial; Ovarian Cancer; Ovarian Neoplasms

Inici: 28/07/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I/II, Open-label, Dose-exploration and Expansion Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of NTX-301 ...

Pinotbio Xennials Therapeutics Australia

Glioblastoma; Glioma; Neoplasms, Unknown Primary; Ovarian Cancer; Ovarian Neoplasms; Urethral Neoplasms; Urinary Bladder Neoplasms

Inici: 25/08/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase 1 Double-Blind, Placebo-Controlled, Single- and Multiple-Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynami...

Johnson & Johnson/Janssen Pharmaceuticals/Momenta Pharmaceuticals

Anemia; Myasthenia Gravis; Systemic Lupus Erythematosus; Unspecified

Inici: 21/05/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Multicenter, Open-label, Single-arm, Phase Ib Study to Evaluate Safety and Efficacy of Mitoxantrone Hydrochloride Liposome Injection in Subjects Wit...

CSPC Pharmaceutical Group Co./CSPC ZhongQi Pharmaceutical Technology Co.

Head and Neck Neoplasms

Inici: 29/06/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

Sequential Infusion of CD19 and BCMA Chimeric Antigen Receptor T Cells to Improve Alloimmune-mediated Platelet Transfusion Refractoriness in Patients ...

(Other Hospital/Academic/Medical Center) Shanghai Unicar-Therapy Bio-medicine Technology Co.

Acute Myelocytic Leukemia; Chronic Lymphocytic Leukemia; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute

Inici: 29/04/2021
Reclutament: 01/01/1900
Final:

Estat: En procés

Detalls / Registre

A Phase I, Dose-escalation Study to Evaluate Safety and Tolerability of Belzutifan (MK-6482) in Participants With Advanced Clear Cell Renal Cell Carci...

Merck & Co./Merck Sharp & Dohme (MSD)

Carcinoma; Carcinoma, Renal Cell; Kidney Neoplasms; Renal Cancer; Wilms Tumor

Inici: 14/06/2021
Reclutament: 01/01/1900
Final:

Estat: En procés